Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 2/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.35 |
| ▸ | TOP2A | P11388 | 15/20 | 0.34 |
| ▸ | TOP2B | Q02880 | 13/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9569173 | 0.82 | STAT3 (0.39) | TOP1STAT3TOP2ATOP2B | |
| SCHEMBL9513057 | 0.82 | TOP1 (0.41) | TOP1STAT3TOP2ATOP2BHPGD | |
| SCHEMBL9560484 | 0.81 | TOP1 (0.41) | TOP1STAT3TOP2ATOP2BHPGD | |
| SCHEMBL9569164 | 0.80 | STAT3 (0.41) | TOP1STAT3TOP2ATOP2B | |
| SCHEMBL9560449 | 0.80 | TOP1 (0.39) | TOP1STAT3TOP2AHPGDHSD17B10 | |
| SCHEMBL9569142 | 0.79 | TOP1 (0.39) | TOP1TOP2ATOP2BKDM4EALDH1A1 | |
| SCHEMBL9509563 | 0.79 | TOP1 (0.40) | TOP1STAT3TOP2ATOP2BHPGD | |
| SCHEMBL6214790 | 0.76 | KDM4E (0.49) | TOP1STAT3HPGDHSD17B10KDM4E | |
| SCHEMBL9560601 | 0.73 | TOP1 (0.45) | TOP1STAT3TOP2ATOP2BHPGD | |
| Hydrochloric Acid SCHEMBL9569157 | 0.72 | CYP11B1 (0.35) | TOP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0563732-A1 | 7-oxo-7H-pyrido(1,2,3-de)(1,4)benzoxazinecarboxylic acids and esters and their use as antiviral agents | BAYER AG (DE) | 1993-10-06 | — | — | EP | disclosed |