Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 4/20 | 0.49 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.44 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.44 |
| ▸ | GRM5 | P41594 | 2/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL945228 | 0.89 | MAP3K5 (0.46) | MAP3K5GRM5 | |
| SCHEMBL945110 | 0.87 | MAP3K5 (0.44) | MAP3K5GRM5 | |
| SCHEMBL943940 | 0.86 | MAP3K5 (0.45) | MAP3K5GRM5GSK3B | |
| SCHEMBL944987 | 0.86 | MYLK (0.54) | MAP3K5 | |
| SCHEMBL945108 | 0.86 | MAP3K5 (0.45) | MAP3K5GRM5 | |
| SCHEMBL944169 | 0.84 | MAP3K5 (0.47) | MAP3K5GRM5ABL1 | |
| SCHEMBL945475 | 0.80 | MAP3K5 (0.43) | MAP3K5GRM5 | |
| SCHEMBL946361 | 0.76 | MAP3K5 (0.53) | MAP3K5GSK3BDYRK1AABL1 | |
| SCHEMBL16382217 | 0.75 | MAP3K5 (0.38) | MAP3K5GRM5 | |
| SCHEMBL945270 | 0.75 | MAP3K5 (0.52) | MAP3K5GRM5ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2454250-A1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | Gilead Sciences, Inc. (US) | 2012-05-23 | — | — | EP | disclosed |
| WO-2011008709-A1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | GILEAD SCIENCES, INC. (US) | 2011-01-20 | — | — | WO | disclosed |