Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | TGM2 | P21980 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyrazine SCHEMBL10495805 | 0.91 | KMT2A (0.40) | NPSR1AKT1TRPM8KMT2AALDH1A1 | |
| Pyridazine SCHEMBL10495810 | 0.89 | NPSR1 (0.34) | NPSR1AKT1TRPM8KMT2AALDH1A1 | |
| SCHEMBL3257322 | 0.83 | NPSR1 (0.44) | NPSR1AKT1TRPM8KMT2AALDH1A1 | |
| SCHEMBL8060946 | 0.82 | NPSR1 (0.40) | NPSR1AKT1TRPM8KMT2AALDH1A1 | |
| SCHEMBL2390372 | 0.81 | NPSR1 (0.43) | NPSR1AKT1TRPM8KMT2AALDH1A1 | |
| SCHEMBL273919 | 0.79 | KMT2A (0.46) | NPSR1AKT1KMT2AALDH1A1POLB | |
| SCHEMBL11703953 | 0.79 | NPSR1 (0.41) | NPSR1AKT1TRPM8KMT2AALDH1A1 | |
| SCHEMBL11883850 | 0.79 | AKT1 (0.43) | NPSR1AKT1TRPM8KMT2AALDH1A1 | |
| SCHEMBL5820979 | 0.78 | AKT1 (0.47) | NPSR1AKT1KMT2AALDH1A1RAB9A | |
| Phenol SCHEMBL29260292 | 0.76 | TDP1 (0.42) | NPSR1AKT1TRPM8KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5198452-A | Leukotriene antagonist, lipoxygenase or cyclooxygenase inhibitors, antihistamines or antiallergens | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1993-03-30 | — | — | US | disclosed |
| EP-0466125-A2 | Styryl compounds and their pharmaceutical use | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1992-01-15 | — | — | EP | disclosed |