SCHEMBL9561356

SCHEMBL9561356

CC(C)(Oc1ccc(NC(=O)Nc2ccccc2Cl)cc1)C(=O)O

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 6/20 0.67
MEN1 O00255 5/20 0.67
KMT2A Q03164 5/20 0.67
LMNA P02545 5/20 0.67
NPSR1 Q6W5P4 2/20 0.67
L3MBTL1 Q9Y468 1/20 0.62
NPC1 O15118 5/20 0.60
RAB9A P51151 5/20 0.60
POLB P06746 2/20 0.60
TDP1 Q9NUW8 2/20 0.60
KDM4E B2RXH2 1/20 0.60
GAA P10253 1/20 0.60
MAPK1 P28482 1/20 0.60
CASP3 P42574 1/20 0.57
SENP8 Q96LD8 1/20 0.57
SENP7 Q9BQF6 1/20 0.57
SENP6 Q9GZR1 1/20 0.57
PPARA Q07869 3/20 0.52
CYP1A2 P05177 1/20 0.52
CYP3A4 P08684 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1305899 0.90 MEN1 (0.63) MAPTMEN1KMT2ALMNANPSR1
SCHEMBL1304683 0.86 PPARA (0.61) MAPTMEN1KMT2ANPC1RAB9A
SCHEMBL9303663 0.85 MEN1 (0.57) MAPTMEN1KMT2ALMNANPSR1
SCHEMBL806016 0.85 PPARA (0.50) MAPTMEN1KMT2ALMNANPSR1
SCHEMBL9303086 0.85 MAPT (0.57) MAPTMEN1KMT2ALMNANPSR1
SCHEMBL805971 0.85 PPARA (0.61) MAPTMEN1KMT2ALMNANPC1
SCHEMBL16303954 0.85 PPARA (0.61) MAPTMEN1KMT2ALMNANPC1
SCHEMBL9131125 0.85 PPARA (0.52) MAPTMEN1KMT2ALMNANPSR1
SCHEMBL1305530 0.84 PPARA (0.55) MAPTMEN1KMT2ALMNANPSR1
SCHEMBL16743448 0.84 MAPT (0.49) MAPTMEN1KMT2ALMNANPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5268500-A Aromatic urea carboxylated compound MONTEFIORE MEDICAL CENTER (US) 1993-12-07 US claimed
EP-0358724-A4 COMPOUND, COMPOSITION AND METHOD FOR THE REDUCTION OF LIPIDS THE MODIFICATION OF THE AFFINITY OF HEMOGLOBIN FOR OXYGEN AND THE PREVENTION OF PLATELET AGGREGATION. LALEZARI IRAJ (US) 1990-06-05 EP claimed
EP-0358724-A1 COMPOUND, COMPOSITION AND METHOD FOR THE REDUCTION OF LIPIDS THE MODIFICATION OF THE AFFINITY OF HEMOGLOBIN FOR OXYGEN AND THE PREVENTION OF PLATELET AGGREGATION LALEZARI, Iraj (US) 1990-03-21 EP claimed
WO-1988010113-A1 COMPOUND, COMPOSITION AND METHOD FOR THE REDUCTION OF LIPIDS THE MODIFICATION OF THE AFFINITY OF HEMOGLOBIN FOR OXYGEN AND THE PREVENTION OF PLATELET AGGREGATION LALEZARI IRAJ (US) 1988-12-29 WO claimed