Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA3 | P07451 | 1/20 | 0.50 |
| ▸ | CA4 | P22748 | 1/20 | 0.50 |
| ▸ | CA6 | P23280 | 1/20 | 0.50 |
| ▸ | CA5A | P35218 | 1/20 | 0.50 |
| ▸ | CA7 | P43166 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.50 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | CES1 | P23141 | 3/20 | 0.41 |
| ▸ | CES2 | O00748 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL9513237 | 1.00 | CA12 (0.50) | CA12CA1CA2CA3CA4 | |
| Bicarbonate SCHEMBL9358118 | 0.88 | CA12 (0.41) | CA12CA1CA2CA3CA4 | |
| SCHEMBL2583573 | 0.84 | ALDH1A1 (0.41) | CA12CA1CA2CA3CA4 | |
| SCHEMBL9309502 | 0.76 | KDM4E (0.47) | CA12CA1CA2CA3CA4 | |
| Alcohol SCHEMBL22497403 | 0.74 | IDO1 (0.35) | ALDH1A1CES1CES2TSHRKDM4E | |
| Benzenethiol SCHEMBL2722939 | 0.73 | MAPT (0.46) | CA12CA1CA2CA3CA4 | |
| SCHEMBL8457762 | 0.71 | ALDH1A1 (0.37) | CA12CA1CA2CA3CA4 | |
| Phenanthrene SCHEMBL28735113 | 0.71 | ALDH1A1 (0.71) | MAPTALDH1A1TSHRKDM4EHPGD | |
| SCHEMBL22931383 | 0.71 | KDM4E (0.46) | MAPTALDH1A1TSHRALOX15KDM4E | |
| Phenanthrene SCHEMBL30702393 | 0.71 | ALDH1A1 (0.71) | MAPTALDH1A1TSHRKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0573866-A1 | Method for forming patterned layers of heat-resistant polycondensates | BASF Lacke + Farben Aktiengesellschaft (DE) | 1993-12-15 | — | — | EP | disclosed |