Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 2/20 | 0.34 |
| ▸ | CTSA | P10619 | 3/20 | 0.32 |
| ▸ | GCGR | P47871 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9562803 | 1.00 | HMGCR (0.34) | HMGCRCTSAGCGR | |
| SCHEMBL9562784 | 0.82 | — | — | |
| SCHEMBL9562809 | 0.82 | HMGCR (0.45) | HMGCR | |
| SCHEMBL9562794 | 0.82 | — | — | |
| SCHEMBL8952914 | 0.80 | NR1I2 (0.33) | CTSA | |
| SCHEMBL8953003 | 0.75 | — | — | |
| SCHEMBL8952769 | 0.73 | ESR1 (0.39) | HMGCR | |
| SCHEMBL8952852 | 0.73 | — | — | |
| SCHEMBL8952778 | 0.73 | ESR1 (0.39) | HMGCR | |
| SCHEMBL8952839 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5202327-A | PHOSPHORUS-CONTAINING HMG-COA REDUCTASE INHIBITORS | E. R. SQUIBB & SONS, INC. (US) | 1993-04-13 | — | — | US | disclosed |
| EP-0522431-A1 | Phophorus-containing HMG-COA reductase inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1993-01-13 | — | — | EP | disclosed |