Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.49 |
| ▸ | DRD1 | P21728 | 2/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.49 |
| ▸ | DRD3 | P35462 | 2/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9563336 | 0.89 | CYP2D6 (0.39) | CYP2D6CHRM2ADRA2ACHRM1DRD1 | |
| SCHEMBL9563322 | 0.88 | HTR1A (0.36) | CYP2D6CHRM2ADRA2ACHRM1DRD1 | |
| SCHEMBL9563244 | 0.82 | CYP2D6 (0.46) | CYP2D6CHRM2ADRA2ACHRM1DRD1 | |
| SCHEMBL9563194 | 0.81 | DRD1 (0.53) | CYP2D6CHRM2ADRA2ACHRM1DRD1 | |
| SCHEMBL9563291 | 0.81 | CYP2D6 (0.43) | CYP2D6CHRM2ADRA2ACHRM1DRD1 | |
| SCHEMBL9563205 | 0.81 | PARP14 (0.58) | CYP2D6CHRM2ADRA2ACHRM1DRD1 | |
| SCHEMBL9563358 | 0.80 | BCHE (0.61) | CYP2D6CHRM2ADRA2ACHRM1DRD1 | |
| SCHEMBL9563228 | 0.79 | BCHE (0.60) | CYP2D6CHRM2ADRA2ACHRM1DRD1 | |
| SCHEMBL9563327 | 0.78 | DRD3 (0.49) | CYP2D6CHRM2ADRA2ACHRM1DRD1 | |
| SCHEMBL9563292 | 0.78 | PARP14 (0.52) | CYP2D6CHRM2ADRA2ACHRM1DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0529365-A1 | Diarylmethoxypiperidine derivatives | Kaken Pharmaceutical Co., Ltd. (JP) | 1993-03-03 | — | — | EP | disclosed |
| US-5190959-A | Antihistamines, antiallergens, treatment of ischemic heart disease | KAKEN PHARMACEUTICAL CO. LTD. (JP) | 1993-03-02 | — | — | US | disclosed |