Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 10/20 | 0.48 |
| ▸ | TOP2B | Q02880 | 10/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | ALB | P02768 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10808897 | 0.77 | TOP2A (0.62) | TOP2ATOP2B | |
| SCHEMBL9377246 | 0.75 | TOP2A (0.55) | TOP2ATOP2BALDH1A1POLBKDM4E | |
| SCHEMBL9377567 | 0.74 | ALDH1A1 (0.53) | TOP2ATOP2BALDH1A1POLB | |
| Bicarbonate SCHEMBL11112814 | 0.73 | TOP2A (0.58) | TOP2ATOP2B | |
| SCHEMBL8131949 | 0.73 | TOP2A (0.63) | TOP2ATOP2B | |
| SCHEMBL9564487 | 0.72 | MEN1 (0.43) | TOP2ATOP2BALDH1A1KDM4EHSD17B10 | |
| SCHEMBL17453750 | 0.71 | TOP2A (0.56) | TOP2ATOP2BALDH1A1POLBKDM4E | |
| SCHEMBL14585956 | 0.71 | ALDH1A1 (0.48) | TOP2ATOP2BALDH1A1POLBKDM4E | |
| SCHEMBL9381212 | 0.71 | KCNH2 (0.53) | TOP2ATOP2BALDH1A1POLB | |
| SCHEMBL10592231 | 0.70 | TOP2A (0.53) | TOP2ATOP2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0531958-A1 | 6-Aminoquinolones, their synthesis and their use as antibacterial agents | MEDIOLANUM FARMACEUTICI S.P.A. (IT) | 1993-03-17 | — | — | EP | disclosed |