SCHEMBL9564815

SCHEMBL9564815

CCn1nnn(CCN2CCC(Nc3nc4cncnc4n3Cc3ccc(F)cc3)CC2)c1=O

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 12/20 0.47
USP2 O75604 11/20 0.47
CYP3A4 P08684 11/20 0.47
CYP2C19 P33261 8/20 0.47
CYP2C9 P11712 8/20 0.47
SSTR5 P35346 4/20 0.47
SMN1; SMN2 Q16637 4/20 0.45
LMNA P02545 4/20 0.45
KCNH2 Q12809 3/20 0.45
HRH1 P35367 2/20 0.45
HRH4 Q9H3N8 2/20 0.45
CYP2D6 P10635 2/20 0.45
EED O75530 2/20 0.45
MEN1 O00255 1/20 0.45
MLNR O43193 1/20 0.45
CACNA1F O60840 1/20 0.45
ABCB11 O95342 1/20 0.45
EGFR P00533 1/20 0.45
HLA-A P04439 1/20 0.45
ERBB2 P04626 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9564810 0.84 SSTR5 (0.53) CYP1A2USP2CYP3A4CYP2C19CYP2C9
SCHEMBL9565058 0.83 SSTR5 (0.54) CYP1A2USP2CYP3A4CYP2C19CYP2C9
SCHEMBL9564897 0.83 SSTR5 (0.54) CYP1A2USP2CYP3A4CYP2C19CYP2C9
SCHEMBL9565027 0.81 SSTR5 (0.55) CYP1A2USP2CYP3A4CYP2C19CYP2C9
SCHEMBL9865967 0.81 CYP3A4 (0.51) CYP1A2USP2CYP3A4CYP2C19CYP2C9
SCHEMBL9631566 0.80 CYP1A2 (0.50) CYP1A2USP2CYP3A4CYP2C19CYP2C9
SCHEMBL9564812 0.79 CYP1A2 (0.52) CYP1A2USP2CYP3A4CYP2C19CYP2C9
SCHEMBL9564822 0.79 KCNH2 (0.48) CYP1A2USP2CYP3A4CYP2C19CYP2C9
SCHEMBL9564831 0.79 SSTR5 (0.52) CYP1A2USP2CYP3A4CYP2C19CYP2C9
SCHEMBL9564866 0.79 SSTR5 (0.52) CYP1A2USP2CYP3A4CYP2C19CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5258380-A Antiallergens, antihistamines JANSSEN PHARMACEUTICA N.V. (BE) 1993-11-02 US disclosed
EP-0206415-B1 (4-PIPERIDINYLMETHYL AND -HETERO)PURINES JANSSEN PHARMACEUTICA N.V. (BE) 1993-01-27 EP disclosed
US-5041448-A Antiallergens JANSSEN PHARMACEUTICA N.V. (BE) 1991-08-20 US disclosed
EP-0206415-A2 (4-Piperidinylmethyl and -hetero)purines JANSSEN PHARMACEUTICA N.V. (BE) 1986-12-30 EP disclosed