Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.48 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.48 |
| ▸ | SSTR5 | P35346 | 8/20 | 0.48 |
| ▸ | USP2 | O75604 | 7/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | EED | O75530 | 2/20 | 0.46 |
| ▸ | HRH1 | P35367 | 2/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MLNR | O43193 | 1/20 | 0.46 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.46 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | HLA-A | P04439 | 1/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9602108 | 0.91 | KCNH2 (0.49) | KCNH2NR4A2SSTR5USP2CYP1A2 | |
| SCHEMBL9564809 | 0.87 | KCNH2 (0.42) | KCNH2NR4A2SSTR5USP2CYP1A2 | |
| SCHEMBL9565058 | 0.86 | SSTR5 (0.54) | KCNH2NR4A2SSTR5USP2CYP1A2 | |
| SCHEMBL9601699 | 0.85 | SSTR5 (0.52) | KCNH2NR4A2SSTR5USP2CYP1A2 | |
| SCHEMBL9564897 | 0.84 | SSTR5 (0.54) | KCNH2NR4A2SSTR5USP2CYP1A2 | |
| SCHEMBL9564810 | 0.84 | SSTR5 (0.53) | KCNH2NR4A2SSTR5USP2CYP1A2 | |
| SCHEMBL9564985 | 0.83 | SSTR5 (0.51) | KCNH2NR4A2SSTR5USP2CYP1A2 | |
| SCHEMBL9564777 | 0.82 | KCNH2 (0.44) | KCNH2NR4A2SSTR5USP2CYP1A2 | |
| SCHEMBL9603207 | 0.82 | KCNH2 (0.44) | KCNH2NR4A2SSTR5USP2CYP1A2 | |
| SCHEMBL9564813 | 0.82 | ALDH1A1 (0.47) | KCNH2NR4A2SSTR5USP2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5258380-A | Antiallergens, antihistamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-11-02 | — | — | US | disclosed |
| US-5041448-A | Antiallergens | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-08-20 | — | — | US | disclosed |
| EP-0206415-A2 | (4-Piperidinylmethyl and -hetero)purines | JANSSEN PHARMACEUTICA N.V. (BE) | 1986-12-30 | — | — | EP | disclosed |