Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | DNMT1 | P26358 | 3/20 | 0.33 |
| ▸ | EHMT2 | Q96KQ7 | 3/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Noberastine SCHEMBL18424 | 0.85 | NR4A2 (0.45) | NR4A2KCNH2SOS1CYP1A2MEN1 | |
| SCHEMBL9564789 | 0.83 | NR4A2 (0.42) | NR4A2KCNH2SOS1CYP1A2CYP3A4 | |
| SCHEMBL10397086 | 0.83 | KCNH2 (0.47) | NR4A2KCNH2SOS1RPS6KA5DYRK1A | |
| Water SCHEMBL9564807 | 0.82 | NR4A2 (0.42) | NR4A2KCNH2SOS1CYP1A2CYP3A4 | |
| Water SCHEMBL9564806 | 0.82 | NR4A2 (0.42) | NR4A2KCNH2SOS1CYP1A2CYP3A4 | |
| SCHEMBL9564774 | 0.82 | ALDH1A1 (0.44) | MEN1KMT2AMAPK8LMNAALDH1A1 | |
| Water SCHEMBL9876754 | 0.80 | KCNH2 (0.46) | NR4A2KCNH2SOS1DYRK1ATSHR | |
| Water SCHEMBL9876758 | 0.80 | KCNH2 (0.46) | NR4A2KCNH2SOS1DYRK1ATSHR | |
| Bromide SCHEMBL9564796 | 0.80 | NR4A2 (0.54) | NR4A2KCNH2SOS1CYP1A2CYP3A4 | |
| SCHEMBL9697200 | 0.80 | KCNH2 (0.62) | NR4A2KCNH2SOS1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5258380-A | Antiallergens, antihistamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-11-02 | — | — | US | disclosed |
| US-5041448-A | Antiallergens | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-08-20 | — | — | US | disclosed |
| EP-0206415-A2 | (4-Piperidinylmethyl and -hetero)purines | JANSSEN PHARMACEUTICA N.V. (BE) | 1986-12-30 | — | — | EP | disclosed |