Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.31 |
| ▸ | RELA | Q04206 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.30 |
| ▸ | F2 | P00734 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7889660 | 0.84 | SMN1; SMN2 (0.43) | SMN1; SMN2ALDH1A1HPGDMAPTTP53 | |
| SCHEMBL7878824 | 0.73 | SMN1; SMN2 (0.42) | SMN1; SMN2ALDH1A1HPGDMAPTTP53 | |
| SCHEMBL9565772 | 0.70 | BAZ2B (0.31) | — | |
| SCHEMBL1335315 | 0.65 | SMN1; SMN2 (0.42) | SMN1; SMN2ALDH1A1HPGDMAPTTP53 | |
| SCHEMBL9451558 | 0.65 | DGAT1 (0.33) | — | |
| SCHEMBL8328430 | 0.64 | NPC1 (0.48) | SMN1; SMN2ALDH1A1MAPTTP53L3MBTL1 | |
| SCHEMBL13915418 | 0.64 | SMN1; SMN2 (0.47) | SMN1; SMN2ALDH1A1HPGDMAPTTP53 | |
| SCHEMBL312896 | 0.64 | SMN1; SMN2 (0.41) | SMN1; SMN2ALDH1A1HPGDMAPTTP53 | |
| SCHEMBL9451680 | 0.63 | DGAT1 (0.34) | — | |
| SCHEMBL9192389 | 0.63 | SMN1; SMN2 (0.52) | SMN1; SMN2ALDH1A1HPGDMAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0576211-A2 | Process for the synthesis of 4-hydroxy-5-halopyrrolo 2,3-D pyrimidine intermediates | ELI LILLY AND COMPANY (US) | 1993-12-29 | — | — | EP | disclosed |
| US-5235053-A | Process for the synthesis of 4-hydroxy-5-halopyrrold[2,3-d]pyrimidine intermediates | ELI LILLY AND COMPANY (US) | 1993-08-10 | — | — | US | disclosed |