Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 10/20 | 0.39 |
| ▸ | TOP2B | Q02880 | 10/20 | 0.39 |
| ▸ | PIM1 | P11309 | 2/20 | 0.36 |
| ▸ | GSK3A | P49840 | 2/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.36 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.36 |
| ▸ | TOP1 | P11387 | 5/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | CHUK | O15111 | 1/20 | 0.31 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.31 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.31 |
| ▸ | PRKCG | P05129 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | MARK3 | P27448 | 1/20 | 0.31 |
| ▸ | AKT1 | P31749 | 1/20 | 0.31 |
| ▸ | AKT2 | P31751 | 1/20 | 0.31 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9568343 | 0.91 | TOP2A (0.42) | TOP2ATOP2BPIM1GSK3AGSK3B | |
| SCHEMBL9568312 | 0.90 | TOP2A (0.41) | TOP2ATOP2BPIM1GSK3AGSK3B | |
| SCHEMBL9568291 | 0.89 | MAPT (0.37) | TOP2ATOP2BTOP1 | |
| SCHEMBL9568346 | 0.89 | TOP1 (0.40) | PIM1GSK3AGSK3BPIM3CSNK1G1 | |
| SCHEMBL9568364 | 0.86 | PIM1 (0.41) | TOP2ATOP2BPIM1GSK3AGSK3B | |
| SCHEMBL9568311 | 0.83 | TOP1 (0.41) | PIM1GSK3AGSK3BPIM3CSNK1G1 | |
| SCHEMBL9568353 | 0.83 | TOP1 (0.36) | PIM1GSK3AGSK3BPIM3TOP1 | |
| SCHEMBL9568305 | 0.80 | MAPT (0.38) | TOP2ATOP2B | |
| SCHEMBL9568329 | 0.80 | MAPT (0.41) | TOP2ATOP2B | |
| SCHEMBL9568342 | 0.79 | TOP1 (0.34) | TOP2ATOP2BPIM1GSK3AGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0551518-A1 | QUINOLINECARBOXYLIC ACID DERIVATIVE | NIPPON SHINYAKU COMPANY, LIMITED (JP) | 1993-07-21 | — | — | EP | disclosed |