Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.72 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.72 |
| ▸ | GABRP | O00591 | 1/20 | 0.72 |
| ▸ | GABRD | O14764 | 1/20 | 0.72 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.72 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.72 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.72 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.72 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.72 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.72 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.72 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.72 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.72 |
| ▸ | GABRE | P78334 | 1/20 | 0.72 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.72 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.72 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.72 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.72 |
| ▸ | BLM | P54132 | 3/20 | 0.69 |
| ▸ | LMNA | P02545 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Isoguvacine SCHEMBL339700 | 0.84 | — | — | |
| SCHEMBL16381920 | 0.82 | TSHR (0.51) | TSHRGABRR1GABRPGABRDGABRA1 | |
| SCHEMBL9497437 | 0.82 | — | — | |
| Isoguvacine SCHEMBL7958625 | 0.82 | BLM (1.00) | TSHRGABRR1GABRPGABRDGABRA1 | |
| Isoguvacine SCHEMBL6214170 | 0.82 | TSHR (0.96) | TSHRGABRR1GABRPGABRDGABRA1 | |
| SCHEMBL2032868 | 0.82 | — | — | |
| Isoguvacine SCHEMBL15260680 | 0.80 | TSHR (0.92) | TSHRGABRR1GABRPGABRDGABRA1 | |
| Hydrochloric Acid SCHEMBL14311854 | 0.80 | BLM (0.68) | TSHRGABRR1GABRPGABRDGABRA1 | |
| Hydrochloric Acid SCHEMBL5249049 | 0.80 | BLM (0.68) | TSHRGABRR1GABRPGABRDGABRA1 | |
| SCHEMBL29439332 | 0.79 | GABRR1 (0.62) | TSHRGABRR1GABRPGABRDGABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0537993-A1 | Nicotinic activity of a series of arecolones and isoarecolones | ELI LILLY AND COMPANY (US) | 1993-04-21 | — | — | EP | disclosed |