Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 7/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.61 |
| ▸ | LMNA | P02545 | 4/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | NR3C1 | P04150 | 7/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.59 |
| ▸ | PGR | P06401 | 4/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.59 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.59 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.59 |
| ▸ | BLM | P54132 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | AR | P10275 | 3/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | APEX1 | P27695 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9569096 | 1.00 | HIF1A (0.61) | HIF1ACYP3A4LMNAALDH1A1NR3C1 | |
| SCHEMBL10702799 | 0.94 | HIF1A (0.58) | HIF1ACYP3A4LMNAALDH1A1NR3C1 | |
| SCHEMBL10702804 | 0.94 | HIF1A (0.58) | HIF1ACYP3A4LMNAALDH1A1NR3C1 | |
| Tipredane SCHEMBL10881220 | 0.92 | HIF1A (0.59) | HIF1ACYP3A4LMNAALDH1A1NR3C1 | |
| Tipredane SCHEMBL9569097 | 0.92 | HIF1A (0.59) | HIF1ACYP3A4LMNAALDH1A1NR3C1 | |
| SCHEMBL10877995 | 0.92 | HIF1A (0.56) | HIF1ACYP3A4LMNAALDH1A1NR3C1 | |
| Tipredane SCHEMBL10881217 | 0.92 | HIF1A (0.59) | HIF1ACYP3A4LMNAALDH1A1NR3C1 | |
| Tipredane SCHEMBL9569094 | 0.92 | HIF1A (0.59) | HIF1ACYP3A4LMNAALDH1A1NR3C1 | |
| Tipredane SCHEMBL5488434 | 0.92 | HIF1A (0.59) | HIF1ACYP3A4LMNAALDH1A1NR3C1 | |
| Tipredane SCHEMBL9569099 | 0.92 | HIF1A (0.59) | HIF1ACYP3A4LMNAALDH1A1NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0524813-A1 | Selective thioketalization process, process for preparing thioenol ethers from thioketals, and process for the preparation of thioketals | E.R. SQUIBB & SONS, INC. (US) | 1993-01-27 | — | — | EP | disclosed |
| EP-0073026-B1 | 17,17-BIS(SUBSTITUTED THIO)-3-KETOANDROSTENES AND PHARMACEUTICAL COMPOSITIONS | E.R. Squibb & Sons, Inc. (US) | 1986-03-19 | — | — | EP | disclosed |
| EP-0073026-A1 | 17,17-Bis(substituted thio)-3-ketoandrostenes and pharmaceutical compositions | E.R. Squibb & Sons, Inc. (US) | 1983-03-02 | — | — | EP | disclosed |
| US-4361559-A | TOPICAL ADMINISTRATION FOR SKIN DISORDERS OF ASTHMA | E. R. SQUIBB & SONS, INC. (US) | 1982-11-30 | — | — | US | disclosed |
| US-4146538-A | STEROIDS, ANTIINFLAMMATORY AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1979-03-27 | — | — | US | disclosed |
| US-4133811-A | ANTIINFLAMMATORY AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1979-01-09 | — | — | US | disclosed |
| US-4094840-A | STEROID, ANTIINFLAMMATORY | E. R. SQUIBB & SONS, INC. (US) | 1978-06-13 | — | — | US | disclosed |
| US-4091036-A | ANTIINFLAMMATORY AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1978-05-23 | — | — | US | disclosed |