Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 7/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.40 |
| ▸ | CDK2 | P24941 | 2/20 | 0.40 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | PARL | Q9H300 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29604813 | 0.85 | CA1 (0.51) | SLC40A1ALDH1A1LMNAHTTKMT2A | |
| SCHEMBL20111657 | 0.85 | CA1 (0.51) | SLC40A1ALDH1A1LMNAHTTKMT2A | |
| SCHEMBL13306694 | 0.82 | CYP2C19 (0.49) | CYP2C19METHTR6CCNE1CDK2 | |
| SCHEMBL1049380 | 0.81 | HTR6 (0.55) | CYP2C19METHTR6CCNE1CDK2 | |
| SCHEMBL959559 | 0.78 | CYP2C19 (0.46) | CYP2C19METHTR6CCNE1CDK2 | |
| SCHEMBL2105176 | 0.77 | CYP2C19 (0.45) | CYP2C19METHTR6CCNE1CDK2 | |
| SCHEMBL29604888 | 0.75 | CA1 (0.47) | MEN1ALDH1A1LMNAHTTKMT2A | |
| SCHEMBL29604761 | 0.74 | CYP2C19 (0.42) | CYP2C19METHTR6CCNE1CDK2 | |
| SCHEMBL8241397 | 0.73 | HTR6 (0.48) | CYP2C19METHTR6CDK2LMNA | |
| SCHEMBL952331 | 0.73 | CYP2C19 (0.44) | CYP2C19METHTR6CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2558469-B1 | PYRROLOPYRAZINONE INHIBITORS OF KINASES | ABBVIE INC (US) | 2014-08-13 | — | — | EP | disclosed |
| EP-2454262-B1 | PYRROLOPYRAZINE INHIBITORS OF KINASES | ABBOTT LAB (US) | 2014-05-14 | — | — | EP | disclosed |
| US-8383624-B2 | Pyrrolopyrazine inhibitors of kinases | ABBOTT LABORATORIES (US) | 2013-02-26 | — | — | US | disclosed |
| EP-2558469-A1 | PYRROLOPYRAZINONE INHIBITORS OF KINASES | Abbvie Inc. (US) | 2013-02-20 | — | — | EP | disclosed |
| CN-102933584-A | Pyrrolopyrazinone inhibitors of kinases | ABBVIE INC | 2013-02-13 | — | — | CN | disclosed |
| EP-2454262-A1 | PYRROLOPYRAZINE INHIBITORS OF KINASES | Abbott Laboratories (US) | 2012-05-23 | — | — | EP | disclosed |
| CN-102471345-A | Pyrrolopyrazine inhibitors of kinases | ABBOTT LAB | 2012-05-23 | — | — | CN | disclosed |
| WO-2011130481-A1 | PYRROLOPYRAZINONE INHIBITORS OF KINASES | ABBOTT LABORATORIES (US) | 2011-10-20 | — | — | WO | disclosed |
| US-20110015172-A1 | PYRROLOPYRAZINE INHIBITORS OF KINASES | ABBOTT LABORATORIES (US) | 2011-01-20 | — | — | US | disclosed |
| WO-2011008830-A1 | PYRROLOPYRAZINE INHIBITORS OF KINASES | ABBOTT LABORATORIES (US) | 2011-01-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110015172-A1 | PYRROLOPYRAZINE INHIBITORS OF KINASES | CDC7, CDK7, CDK17 | CYP2C19 3532/4885MET 2469/4885HTR6 4700/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.