Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 5/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.35 |
| ▸ | MIF | P14174 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 2/20 | 0.34 |
| ▸ | MAOA | P21397 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | METAP2 | P50579 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7491461 | 0.75 | APP (0.44) | MAOBAPPPIM1CYP2A6MIF | |
| SCHEMBL1655877 | 0.72 | FLT3 (0.50) | MAOBCYP2A6MAOAMEN1KMT2A | |
| SCHEMBL13197119 | 0.72 | NPC1 (0.56) | MAOBAPPPIM1CYP2A6MIF | |
| SCHEMBL16795610 | 0.72 | ALDH1A1 (0.53) | MAOBPIM1MIFMAOAMEN1 | |
| SCHEMBL19282095 | 0.71 | MAOB (0.42) | MAOBAPPPIM1CYP2A6MIF | |
| SCHEMBL31031658 | 0.71 | MAOB (0.42) | MAOBAPPPIM1CYP2A6MIF | |
| SCHEMBL2095773 | 0.71 | MAOB (0.42) | MAOBAPPPIM1CYP2A6MIF | |
| SCHEMBL12278485 | 0.71 | PIM1 (0.44) | PIM1NPC1RAB9A | |
| SCHEMBL5028081 | 0.71 | FLT3 (0.65) | MAOBPIM1MEN1KMT2ACYP1A2 | |
| SCHEMBL16403660 | 0.71 | MCL1 (0.42) | MAOBAPPCYP2A6MIFMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0560554-A2 | Antitumor compositions and methods of treatment | ELI LILLY AND COMPANY (US) | 1993-09-15 | — | — | EP | disclosed |
| US-5169860-A | Benzofuran or benzothiophene arylsulfonylureas | ELI LILLY AND COMPANY (US) | 1992-12-08 | — | — | US | disclosed |