Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC5 | P28715 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | KLKB1 | P03952 | 3/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | RBP4 | P02753 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9934111 | 0.85 | ERCC5 (0.35) | ERCC5PDE4AKLKB1RBP4 | |
| SCHEMBL2066942 | 0.82 | CDK2 (0.35) | ERCC5PDE4APDE10AALDH1A1SMN1; SMN2 | |
| SCHEMBL18209511 | 0.82 | HRH1 (0.40) | ERCC5KLKB1PDE10A | |
| SCHEMBL7969411 | 0.82 | KLKB1 (0.34) | ERCC5PDE4AKLKB1PDE10ARBP4 | |
| SCHEMBL876570 | 0.78 | KLKB1 (0.33) | ERCC5KLKB1RBP4SMN1; SMN2 | |
| SCHEMBL2066642 | 0.78 | PDE4A (0.35) | ERCC5PDE4AKLKB1RBP4ALDH1A1 | |
| SCHEMBL7979633 | 0.76 | ERCC5 (0.34) | ERCC5PDE4AKLKB1RBP4 | |
| SCHEMBL5148627 | 0.75 | POLB (0.35) | ERCC5PDE4AKLKB1RBP4ALDH1A1 | |
| SCHEMBL5148620 | 0.75 | ERCC5 (0.32) | ERCC5KLKB1RBP4 | |
| SCHEMBL9968611 | 0.74 | PDE4A (0.33) | ERCC5PDE4AKLKB1RBP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5270322-A | Imidazo[1,2-a]pyridines, pharmaceutical compositions containing these compounds and processes for preparing them | DR. KARL THOMAE GMBH (DE) | 1993-12-14 | — | — | US | disclosed |
| EP-0555825-A1 | Imidazo(1,2-a)pyridines as angiotensin-II-antagonists | Dr. Karl Thomae GmbH (DE) | 1993-08-18 | — | — | EP | disclosed |