Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 3/20 | 0.34 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | RBP4 | P02753 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18209511 | 0.82 | HRH1 (0.40) | KLKB1ERCC5PDE10A | |
| SCHEMBL2066942 | 0.82 | CDK2 (0.35) | ERCC5PDE10APDE4A | |
| SCHEMBL9569919 | 0.82 | ERCC5 (0.34) | KLKB1ERCC5PDE10ARBP4PDE4A | |
| SCHEMBL16188722 | 0.78 | KCNH2 (0.47) | — | |
| SCHEMBL9934111 | 0.78 | ERCC5 (0.35) | KLKB1ERCC5RBP4PDE4A | |
| SCHEMBL2066642 | 0.78 | PDE4A (0.35) | KLKB1ERCC5RBP4PDE4A | |
| SCHEMBL876570 | 0.78 | KLKB1 (0.33) | KLKB1ERCC5RBP4 | |
| SCHEMBL7979633 | 0.76 | ERCC5 (0.34) | KLKB1ERCC5RBP4PDE4A | |
| SCHEMBL9968611 | 0.74 | PDE4A (0.33) | KLKB1ERCC5RBP4PDE4A | |
| SCHEMBL21368088 | 0.74 | KDM4E (0.47) | KLKB1ERCC5RBP4PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6174877-B1 | EXCELLANT BACTERICIDES, ORAL ABSORBABILITY AND STABILITY; IMPROVE THE STABILITY TO RENAL DEHYDROPEPTIDASE I (DHP-I); 2-(2-(N-HETEROCYCLIC-ETHYLTHIO-) DERIVATIVES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-01-16 | — | — | US | disclosed |
| EP-0876370-A1 | CARBAPENEM COMPOUNDS, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1998-11-11 | — | — | EP | disclosed |
| WO-1997025325-A1 | CARBAPENEM COMPOUNDS, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-07-17 | — | — | WO | disclosed |
| US-5270322-A | Imidazo[1,2-a]pyridines, pharmaceutical compositions containing these compounds and processes for preparing them | DR. KARL THOMAE GMBH (DE) | 1993-12-14 | — | — | US | disclosed |