Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | NPC1 | O15118 | 4/20 | 0.60 |
| ▸ | RAB9A | P51151 | 4/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.60 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14050118 | 0.85 | MAPT (0.76) | HDAC6MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL243922 | 0.85 | LMNA (0.61) | HDAC6MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3640134 | 0.84 | LMNA (0.64) | HDAC6MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL17933573 | 0.82 | MAPT (0.62) | HDAC6MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL28038284 | 0.82 | MAPT (0.67) | HDAC6MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL855166 | 0.82 | MAPT (0.77) | HDAC6MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4728786 | 0.82 | HDAC6 (0.67) | HDAC6MAPTNPC1RAB9ASMN1; SMN2 | |
| Iodide SCHEMBL3451153 | 0.82 | LMNA (0.62) | HDAC6MAPTNPC1RAB9ASMN1; SMN2 | |
| Iodide SCHEMBL3451154 | 0.82 | LMNA (0.62) | HDAC6MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2792751 | 0.81 | LMNA (0.61) | HDAC6MAPTNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5270322-A | Imidazo[1,2-a]pyridines, pharmaceutical compositions containing these compounds and processes for preparing them | DR. KARL THOMAE GMBH (DE) | 1993-12-14 | — | — | US | disclosed |
| EP-0555825-A1 | Imidazo(1,2-a)pyridines as angiotensin-II-antagonists | Dr. Karl Thomae GmbH (DE) | 1993-08-18 | — | — | EP | disclosed |