Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9570452 | 0.88 | TNF (0.47) | TNFMAPTTDP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL21378150 | 0.85 | MAPT (0.58) | TNFMAPTHSD17B10TDP1FGFR1 | |
| SCHEMBL19296053 | 0.85 | LMNA (0.53) | TNFMAPTHSD17B10TDP1FGFR1 | |
| SCHEMBL20125126 | 0.83 | MAPT (0.53) | TNFMAPTHSD17B10TDP1FGFR1 | |
| SCHEMBL9596940 | 0.83 | MAPT (0.49) | TNFMAPTHSD17B10TDP1FGFR1 | |
| SCHEMBL19911314 | 0.82 | LMNA (0.67) | TNFMAPTHSD17B10TDP1FGFR1 | |
| SCHEMBL10600757 | 0.81 | NPC1 (0.62) | TNFMAPTHSD17B10TDP1FGFR1 | |
| SCHEMBL18731436 | 0.81 | MAPT (0.46) | TNFMAPTHSD17B10TDP1FGFR1 | |
| SCHEMBL18250746 | 0.81 | MAPT (0.46) | TNFMAPTHSD17B10TDP1FGFR1 | |
| SCHEMBL11085471 | 0.81 | MAPT (0.58) | TNFMAPTHSD17B10TDP1FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5270322-A | Imidazo[1,2-a]pyridines, pharmaceutical compositions containing these compounds and processes for preparing them | DR. KARL THOMAE GMBH (DE) | 1993-12-14 | — | — | US | disclosed |
| EP-0555825-A1 | Imidazo(1,2-a)pyridines as angiotensin-II-antagonists | Dr. Karl Thomae GmbH (DE) | 1993-08-18 | — | — | EP | disclosed |