Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 5/20 | 0.63 |
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | RECQL | P46063 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9569962 | 0.99 | TP53 (0.65) | TP53LMNASMN1; SMN2TLR8POLB | |
| SCHEMBL9570117 | 0.94 | GAA (0.64) | TP53LMNASMN1; SMN2TLR8POLB | |
| SCHEMBL28716632 | 0.90 | LMNA (0.67) | TP53LMNASMN1; SMN2TLR8POLB | |
| SCHEMBL28879087 | 0.90 | LMNA (0.67) | TP53LMNASMN1; SMN2TLR8POLB | |
| SCHEMBL29968482 | 0.90 | LMNA (0.67) | TP53LMNASMN1; SMN2TLR8POLB | |
| SCHEMBL28860662 | 0.90 | LMNA (0.67) | TP53LMNASMN1; SMN2TLR8POLB | |
| SCHEMBL29968953 | 0.90 | LMNA (0.67) | TP53LMNASMN1; SMN2TLR8POLB | |
| SCHEMBL28879019 | 0.90 | LMNA (0.67) | TP53LMNASMN1; SMN2TLR8POLB | |
| SCHEMBL28878994 | 0.90 | LMNA (0.67) | TP53LMNASMN1; SMN2TLR8POLB | |
| SCHEMBL28717937 | 0.90 | LMNA (0.71) | TP53LMNASMN1; SMN2TLR8POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5270322-A | Imidazo[1,2-a]pyridines, pharmaceutical compositions containing these compounds and processes for preparing them | DR. KARL THOMAE GMBH (DE) | 1993-12-14 | — | — | US | disclosed |
| EP-0555825-A1 | Imidazo(1,2-a)pyridines as angiotensin-II-antagonists | Dr. Karl Thomae GmbH (DE) | 1993-08-18 | — | — | EP | disclosed |