Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.43 |
| ▸ | F9 | P00740 | 1/20 | 0.42 |
| ▸ | CACNA1H | O95180 | 4/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5681326 | 0.85 | CACNA1H (0.56) | PDE10ANTRK1NTRK2F9CACNA1H | |
| SCHEMBL9597974 | 0.85 | PDE10A (0.47) | PDE10ANTRK1NTRK2F9CACNA1H | |
| SCHEMBL11973911 | 0.85 | PDE10A (0.47) | PDE10ANTRK1NTRK2F9CACNA1H | |
| SCHEMBL5681369 | 0.82 | RAD52 (0.51) | PDE10ANTRK1NTRK2F9CACNA1H | |
| SCHEMBL38661777 | 0.81 | CACNA1H (0.62) | PDE10ACACNA1HIDO1NPBWR1MAOB | |
| SCHEMBL4556153 | 0.81 | TDP1 (0.47) | PDE10ANTRK1NTRK2F9CACNA1H | |
| SCHEMBL367831 | 0.81 | IDO1 (0.45) | PDE10ANTRK1NTRK2CACNA1HIDO1 | |
| SCHEMBL10284701 | 0.81 | DDAH1 (0.53) | PDE10ACACNA1HIDO1NPBWR1KDM4E | |
| SCHEMBL9281215 | 0.81 | RAD52 (0.47) | PDE10ANTRK1NTRK2F9CACNA1H | |
| SCHEMBL3372786 | 0.79 | MAOB (0.46) | PDE10ANTRK1NTRK2F9CACNA1H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5270322-A | Imidazo[1,2-a]pyridines, pharmaceutical compositions containing these compounds and processes for preparing them | DR. KARL THOMAE GMBH (DE) | 1993-12-14 | — | — | US | disclosed |
| EP-0555825-A1 | Imidazo(1,2-a)pyridines as angiotensin-II-antagonists | Dr. Karl Thomae GmbH (DE) | 1993-08-18 | — | — | EP | disclosed |