Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 9/20 | 0.49 |
| ▸ | NPC1 | O15118 | 5/20 | 0.49 |
| ▸ | RAB9A | P51151 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9597830 | 0.90 | KDM4E (0.54) | KDM4EHDAC6NPC1RAB9AMAPT | |
| SCHEMBL24661295 | 0.87 | KDM4E (0.52) | KDM4EHDAC6NPC1RAB9AMAPT | |
| SCHEMBL29703923 | 0.87 | KDM4E (0.52) | KDM4EHDAC6NPC1RAB9AMAPT | |
| SCHEMBL9597035 | 0.85 | HDAC6 (0.50) | HDAC6NPC1RAB9ASMN1; SMN2HDAC1 | |
| SCHEMBL9570120 | 0.84 | HDAC6 (0.53) | HDAC6NPC1RAB9ASMN1; SMN2HDAC1 | |
| SCHEMBL6475543 | 0.81 | KDM4E (0.48) | KDM4EHDAC6NPC1RAB9AMAPT | |
| SCHEMBL6512715 | 0.81 | NPC1 (0.51) | KDM4ENPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL15020122 | 0.79 | KDM4E (0.49) | KDM4EHDAC6NPC1RAB9AMAPT | |
| SCHEMBL23280181 | 0.79 | IDH1 (0.60) | KDM4EHDAC6NPC1RAB9ALMNA | |
| SCHEMBL31489 | 0.79 | RAB9A (0.72) | KDM4EHDAC6NPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5270322-A | Imidazo[1,2-a]pyridines, pharmaceutical compositions containing these compounds and processes for preparing them | DR. KARL THOMAE GMBH (DE) | 1993-12-14 | — | — | US | disclosed |
| EP-0555825-A1 | Imidazo(1,2-a)pyridines as angiotensin-II-antagonists | Dr. Karl Thomae GmbH (DE) | 1993-08-18 | — | — | EP | disclosed |