Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.61 |
| ▸ | NPC1 | O15118 | 7/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.58 |
| ▸ | MAPT | P10636 | 5/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.53 |
| ▸ | RELA | Q04206 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9570359 | 0.86 | KDM4E (0.59) | RAB9ANPC1SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL103116 | 0.86 | RAB9A (0.61) | RAB9ANPC1SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL7112860 | 0.84 | RAB9A (0.60) | RAB9ANPC1SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL103671 | 0.84 | NPC1 (0.60) | RAB9ANPC1SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL9570110 | 0.84 | RAB9A (0.60) | RAB9ANPC1SMN1; SMN2ALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL29899398 | 0.83 | RAB9A (0.58) | RAB9ANPC1SMN1; SMN2ALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL29899408 | 0.83 | RAB9A (0.58) | RAB9ANPC1SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL12092516 | 0.83 | RAB9A (0.62) | RAB9ANPC1SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL14038137 | 0.82 | KDM4E (0.45) | RAB9ANPC1SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL14736747 | 0.81 | NPC1 (0.57) | RAB9ANPC1SMN1; SMN2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5270322-A | Imidazo[1,2-a]pyridines, pharmaceutical compositions containing these compounds and processes for preparing them | DR. KARL THOMAE GMBH (DE) | 1993-12-14 | — | — | US | disclosed |
| EP-0555825-A1 | Imidazo(1,2-a)pyridines as angiotensin-II-antagonists | Dr. Karl Thomae GmbH (DE) | 1993-08-18 | — | — | EP | disclosed |