Known targets — ChEMBL curated mechanism
DRD2DRD3DRD4GNRHRHRH1HTR2AHTR2CSLC6A2SLC6A4SSTR1SSTR2SSTR3SSTR5
The experimentally established mechanism targets of Pamoic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 4/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | CLK2 | P49760 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6212469 | 0.86 | KDM4E (0.64) | ALDH1A1KDM4EHPGDHSD17B10MEN1 | |
| SCHEMBL7502048 | 0.86 | KDM4E (0.64) | ALDH1A1KDM4EHPGDHSD17B10MEN1 | |
| Hydrochloric Acid SCHEMBL6216048 | 0.85 | KDM4E (0.65) | ALDH1A1KDM4EHPGDHSD17B10MEN1 | |
| Hydrochloric Acid SCHEMBL1859198 | 0.85 | KDM4E (0.65) | ALDH1A1KDM4EHPGDHSD17B10MEN1 | |
| Sulfuric Acid SCHEMBL9570920 | 0.83 | KDM4E (0.60) | ALDH1A1KDM4EHPGDHSD17B10MEN1 | |
| Phenylmethanesulfonic Acid SCHEMBL9570841 | 0.83 | KDM4E (0.53) | ALDH1A1KDM4EHPGDHSD17B10MEN1 | |
| SCHEMBL6212466 | 0.81 | ALDH1A1 (0.76) | ALDH1A1KDM4EHPGDHSD17B10MEN1 | |
| SCHEMBL7502039 | 0.81 | ALDH1A1 (0.76) | ALDH1A1KDM4EHPGDHSD17B10MEN1 | |
| Citric Acid SCHEMBL9570761 | 0.80 | ALDH1A1 (0.55) | ALDH1A1KDM4EHPGDHSD17B10MEN1 | |
| Hydrochloric Acid SCHEMBL8740953 | 0.80 | ALDH1A1 (0.78) | ALDH1A1KDM4EHPGDHSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0550903-A1 | Quinolone- and naphthyridone carboxylic acid derivatives as antibacterial agents | BAYER AG (DE) | 1993-07-14 | — | — | EP | disclosed |