Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 4/20 | 0.67 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.67 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.67 |
| ▸ | LMNA | P02545 | 2/20 | 0.67 |
| ▸ | USP2 | O75604 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.67 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.67 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.67 |
| ▸ | GMNN | O75496 | 1/20 | 0.66 |
| ▸ | APEX1 | P27695 | 1/20 | 0.66 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nuvenzepine SCHEMBL1817515 | 0.92 | CHRM2 (0.56) | CHRM2CHRM1CHRM4LMNAUSP2 | |
| SCHEMBL9405297 | 0.88 | CHRM2 (0.60) | CHRM2CHRM1CHRM4LMNAUSP2 | |
| SCHEMBL10878225 | 0.85 | CHRM2 (0.64) | CHRM2CHRM1CHRM4LMNAUSP2 | |
| SCHEMBL10737034 | 0.85 | CHRM2 (0.52) | CHRM2CHRM1CHRM4LMNAUSP2 | |
| SCHEMBL10874963 | 0.85 | CHRM2 (0.72) | CHRM2CHRM1CHRM4LMNAUSP2 | |
| SCHEMBL9674508 | 0.85 | CHRM2 (0.64) | CHRM2CHRM1CHRM4LMNAUSP2 | |
| SCHEMBL10876532 | 0.85 | CHRM2 (0.64) | CHRM2CHRM1CHRM4LMNAUSP2 | |
| Hydrochloric Acid SCHEMBL9676158 | 0.84 | LMNA (0.65) | CHRM2CHRM1CHRM4LMNAUSP2 | |
| SCHEMBL11203450 | 0.84 | CHRM2 (0.63) | CHRM2CHRM1CHRM4LMNAUSP2 | |
| SCHEMBL26853334 | 0.83 | LMNA (0.73) | CHRM2CHRM1CHRM4LMNAUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0556947-A1 | Use of M1-selective antimuscarinic pyridobenzodiazepinones for the treatment and prevention of axial myopia | MERCK & CO. INC. (US) | 1993-08-25 | — | — | EP | disclosed |
| US-4556653-A | ANTISECRETORY, ANTIULCER AND ANTISPASMODIC AGENTS | DOMPE' FARMACEUTICA S.P.A. (IT) | 1985-12-03 | — | — | US | disclosed |
| EP-0125607-A2 | Pyrido(1,5)benzodiazepinone derivatives and pharmacological activities thereof | DOMPE' FARMACEUTICI S.p.A. (IT) | 1984-11-21 | — | — | EP | disclosed |