Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.44 |
| ▸ | AGXT | P21549 | 2/20 | 0.44 |
| ▸ | GBA1 | P04062 | 1/20 | 0.43 |
| ▸ | UGCG | Q16739 | 1/20 | 0.43 |
| ▸ | GBA2 | Q9HCG7 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 5/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7741926 | 1.00 | IDO1 (0.44) | IDO1AGXTGBA1UGCGGBA2 | |
| SCHEMBL7236826 | 0.98 | IDO1 (0.45) | IDO1AGXTGBA1UGCGGBA2 | |
| SCHEMBL7239991 | 0.92 | IDO1 (0.47) | IDO1AGXTGBA1UGCGGBA2 | |
| SCHEMBL1964901 | 0.84 | IDO1 (0.50) | IDO1AGXTL3MBTL1MAOBAPP | |
| SCHEMBL9574237 | 0.84 | TAAR1 (0.39) | TDP1L3MBTL1MAOB | |
| SCHEMBL9574248 | 0.84 | TAAR1 (0.39) | IDO1AGXTMAOB | |
| SCHEMBL7010371 | 0.81 | IDO1 (0.44) | IDO1AGXTGBA1UGCGGBA2 | |
| SCHEMBL7228810 | 0.81 | TAAR1 (0.41) | IDO1AGXTMAOB | |
| SCHEMBL1008118 | 0.81 | GBA1 (0.49) | IDO1AGXTGBA1UGCGGBA2 | |
| SCHEMBL4229986 | 0.81 | L3MBTL1 (0.54) | IDO1GBA1UGCGGBA2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1129599-C | Substituted benzothiazine/oxazine-2-amine derivatives, co-preparation method and application thereof | PF MEDICAMENT (FR) | 2003-12-03 | — | — | CN | disclosed |
| US-6531469-B1 | Treatment of myocardial ischemia, chronic stable angina, unstable angina and prinzmetal's angina attacks, silent cardiac ischemia, reinfarction, reocclusion and restenosis | PIERRE FABRE MEDICAMENT (FR) | 2003-03-11 | — | — | US | disclosed |
| EP-1144408-B1 | SUBSTITUTED 1-(PIERIDIN-4-YL)-3-(ARYL) ISOTHIOUREAS THEIR PREPARATION AND THERAPEUTIC APPLICATION | PF MEDICAMENT (FR) | 2002-09-25 | — | — | EP | disclosed |
| EP-1144408-A1 | SUBSTITUTED 1-(PIERIDIN-4-YL)-3-(ARYL) ISOTHIOUREAS THEIR PREPARATION AND THERAPEUTIC APPLICATION | PIERRE FABRE MEDICAMENT (FR) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000043391-A1 | SUBSTITUTED 1-(PIERIDIN-4-YL)-3-(ARYL) ISOTHIOUREAS THEIR PREPARATION AND THERAPEUTIC APPLICATION | PIERRE FABRE MEDICAMENT (FR) | 2000-07-27 | — | — | WO | disclosed |