Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | EBP | Q15125 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | DRD3 | P35462 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.41 |
| ▸ | XPO1 | O14980 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | DHCR7 | Q9UBM7 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL957516 | 1.00 | KMT2A (0.43) | KMT2AEBPSIGMAR1RXFP1DRD2 | |
| SCHEMBL952446 | 0.90 | EBP (0.51) | KMT2AEBPSIGMAR1DRD2DRD3 | |
| SCHEMBL952443 | 0.90 | EBP (0.51) | KMT2AEBPSIGMAR1DRD2DRD3 | |
| SCHEMBL952076 | 0.90 | KDM4E (0.43) | KMT2ADRD2DRD3LMNAMEN1 | |
| SCHEMBL952075 | 0.90 | KDM4E (0.43) | KMT2ADRD2DRD3LMNAMEN1 | |
| SCHEMBL955892 | 0.85 | MEN1 (0.52) | KMT2AEBPSIGMAR1DRD2DRD3 | |
| SCHEMBL955890 | 0.85 | MEN1 (0.52) | KMT2AEBPSIGMAR1DRD2DRD3 | |
| SCHEMBL952590 | 0.84 | DRD2 (0.48) | KMT2AEBPSIGMAR1DRD2DRD3 | |
| SCHEMBL952589 | 0.84 | DRD2 (0.48) | KMT2AEBPSIGMAR1DRD2DRD3 | |
| SCHEMBL953632 | 0.82 | KMT2A (0.39) | KMT2ARXFP1DRD2DRD3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8796274-B2 | Piperazine derivatives and their use in controlling pests | SYNGENTA CROP PROTECTION LLC (US) | 2014-08-05 | — | — | US | disclosed |
| EP-1755396-B1 | PIPERAZIN DERIVATIVES AND THEIR USE IN CONTROLLING PESTS | SYNGENTA PARTICIPATIONS AG (CH) | 2014-06-18 | — | — | EP | disclosed |
| US-20110003991-A1 | PIPERAZINE DERIVATIVES AND THEIR USE IN CONTROLLING PESTS | SYNGENTA CROP PROTECTION, INC. (US) | 2011-01-06 | — | — | US | disclosed |
| US-7807679-B2 | 2-chloro-N-(4-chloro-2-{4-[(E)-3-(4-chloro-phenyl)-allyl]-piperazin-1-yl}-phenyl)-isonicotinamide; for insects, acarines, nematodes and molluscs | SYNGENTA CROP PROTECTION, INC. (US) | 2010-10-05 | — | — | US | disclosed |
| US-20080076777-A1 | 2-chloro-N-(4-chloro-2-{4-[(E)-3-(4-chloro-phenyl)-allyl]-piperazin-1-yl}-phenyl)-isonicotinamide; for insects, acarines, nematodes and molluscs | SYNGENTA CROP PROTECTION, INC. (US) | 2008-03-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110003991-A1 | PIPERAZINE DERIVATIVES AND THEIR USE IN CONTROLLING PESTS | CHRM1, CHRM5, PRMT5 | KMT2A 1508/4885EBP 3189/4885SIGMAR1 160/4885 |
| US-20080076777-A1 | 2-chloro-N-(4-chloro-2-{4-[(E)-3-(4-chloro-phenyl)-allyl]-piperazin-1-yl}-phenyl)-isonicotinamide; for insects, acarines, nematodes and molluscs | CHRM1, CHRM2, CHRM5 | KMT2A 842/4885EBP 1998/4885SIGMAR1 259/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.