Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 2/20 | 0.43 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.43 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.43 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | TLR2 | O60603 | 7/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10942611 | 0.88 | PLA2G2A (0.44) | PLA2G2APLA2G10PLA2G1BPLA2G5NPC1 | |
| SCHEMBL10940306 | 0.88 | PLA2G2A (0.44) | PLA2G2APLA2G10PLA2G1BPLA2G5NPC1 | |
| SCHEMBL10937042 | 0.88 | PLA2G2A (0.44) | PLA2G2APLA2G10PLA2G1BPLA2G5NPC1 | |
| SCHEMBL10944558 | 0.88 | PLA2G2A (0.44) | PLA2G2APLA2G10PLA2G1BPLA2G5NPC1 | |
| SCHEMBL11129254 | 0.88 | PLA2G2A (0.44) | PLA2G2APLA2G10PLA2G1BPLA2G5NPC1 | |
| SCHEMBL10946092 | 0.88 | PLA2G2A (0.44) | PLA2G2APLA2G10PLA2G1BPLA2G5NPC1 | |
| SCHEMBL30866269 | 0.86 | PLA2G2A (0.44) | PLA2G2APLA2G10PLA2G1BPLA2G5TLR2 | |
| SCHEMBL11128609 | 0.86 | PLA2G2A (0.44) | PLA2G2APLA2G10PLA2G1BPLA2G5TLR2 | |
| SCHEMBL10598820 | 0.85 | MEN1 (0.48) | PLA2G2APLA2G10PLA2G1BPLA2G5TLR2 | |
| SCHEMBL9669469 | 0.85 | HDAC6 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5187293-A | Blood platelet activating factor inhibitors | HOFFMANN-LA ROCHE INC. (US) | 1993-02-16 | — | — | US | disclosed |
| EP-0147768-B1 | GLYCERIN DERIVATIVES | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1989-02-08 | — | — | EP | disclosed |
| US-4731373-A | BLOOD PLATELET ACTIVATING FACTOR | HOFFMAN-LA ROCHE INC. (US) | 1988-03-15 | — | — | US | disclosed |
| EP-0147768-A2 | Glycerin derivatives | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1985-07-10 | — | — | EP | disclosed |