Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | GMNN | O75496 | 1/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
| ▸ | PTAFR | P25105 | 1/20 | 0.59 |
| ▸ | MTOR | P42345 | 1/20 | 0.59 |
| ▸ | BLM | P54132 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL9575698 | 1.00 | LMNA (0.59) | LMNAGMNNUSP2PTAFRMTOR | |
| Iodide SCHEMBL9575691 | 1.00 | LMNA (0.59) | LMNAGMNNUSP2PTAFRMTOR | |
| SCHEMBL10505894 | 0.99 | LMNA (0.60) | LMNAGMNNUSP2PTAFRMTOR | |
| SCHEMBL10506196 | 0.91 | GMNN (0.69) | LMNAGMNNUSP2PTAFRMTOR | |
| Hydrochloric Acid SCHEMBL9575824 | 0.90 | GMNN (0.68) | LMNAGMNNUSP2PTAFRMTOR | |
| Iodide SCHEMBL9117189 | 0.89 | GMNN (0.61) | LMNAGMNNUSP2PTAFRMTOR | |
| Iodide SCHEMBL9117195 | 0.89 | GMNN (0.61) | LMNAGMNNUSP2PTAFRMTOR | |
| SCHEMBL9120153 | 0.88 | GMNN (0.62) | LMNAGMNNUSP2PTAFRMTOR | |
| SCHEMBL9120138 | 0.88 | GMNN (0.62) | LMNAGMNNUSP2PTAFRMTOR | |
| Iodide SCHEMBL9575875 | 0.87 | LMNA (0.45) | LMNAGMNNUSP2PTAFRMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0147768-B1 | GLYCERIN DERIVATIVES | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1989-02-08 | — | — | EP | claimed |
| US-4731373-A | BLOOD PLATELET ACTIVATING FACTOR | HOFFMAN-LA ROCHE INC. (US) | 1988-03-15 | — | — | US | claimed |
| US-5187293-A | Blood platelet activating factor inhibitors | HOFFMANN-LA ROCHE INC. (US) | 1993-02-16 | — | — | US | disclosed |
| US-4731373-A | BLOOD PLATELET ACTIVATING FACTOR | HOFFMAN-LA ROCHE INC. (US) | 1988-03-15 | — | — | US | disclosed |