Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.37 |
| ▸ | CHRM4 known ✓ | P08173 | 1/20 | 0.37 |
| ▸ | CHRM5 known ✓ | P08912 | 1/20 | 0.37 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.37 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.37 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.37 |
| ▸ | TLR2 | O60603 | 5/20 | 0.51 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.37 |
| ▸ | RAD52 | P43351 | 2/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.37 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL9575815 | 1.00 | TLR2 (0.51) | TLR2HSP90AA1RAD52EGFRLMNA | |
| Bromide SCHEMBL9575953 | 0.86 | RAD52 (0.50) | HSP90AA1RAD52EGFRLMNAPLA2G1B | |
| Bromide SCHEMBL9575965 | 0.80 | EPHX1 (0.39) | HSP90AA1RAD52EGFRLMNAPLA2G1B | |
| Bromide SCHEMBL9575963 | 0.80 | EPHX1 (0.39) | HSP90AA1RAD52EGFRLMNAPLA2G1B | |
| Bromide SCHEMBL9575968 | 0.80 | EPHX1 (0.39) | HSP90AA1RAD52EGFRLMNAPLA2G1B | |
| Hydrochloric Acid SCHEMBL9575952 | 0.80 | ALDH1A1 (0.46) | LMNAKMT2ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL9575957 | 0.80 | ALDH1A1 (0.46) | LMNAKMT2ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL9575947 | 0.80 | ALDH1A1 (0.46) | LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL10833182 | 0.76 | PTAFR (0.52) | LMNATSHRHTR2CKMT2ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL9576049 | 0.72 | GMNN (0.39) | LMNATSHRKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5187293-A | Blood platelet activating factor inhibitors | HOFFMANN-LA ROCHE INC. (US) | 1993-02-16 | — | — | US | disclosed |
| US-4731373-A | BLOOD PLATELET ACTIVATING FACTOR | HOFFMAN-LA ROCHE INC. (US) | 1988-03-15 | — | — | US | disclosed |