Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR2 | O60603 | 8/20 | 0.45 |
| ▸ | CETP | P11597 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9863402 | 0.84 | TLR2 (0.49) | TLR2L3MBTL1LMNA | |
| SCHEMBL10605748 | 0.83 | PLA2G10 (0.47) | TLR2CETPTDP1L3MBTL1PLA2G10 | |
| SCHEMBL10604671 | 0.83 | PLA2G10 (0.47) | TLR2CETPTDP1L3MBTL1PLA2G10 | |
| SCHEMBL18641859 | 0.83 | PLA2G10 (0.47) | TLR2CETPTDP1L3MBTL1PLA2G10 | |
| SCHEMBL10604578 | 0.83 | PLA2G10 (0.47) | TLR2CETPTDP1L3MBTL1PLA2G10 | |
| SCHEMBL26277061 | 0.82 | TLR2 (0.48) | TLR2CETPALDH1A1TSHRCYP3A4 | |
| SCHEMBL4483073 | 0.81 | CETP (0.50) | TLR2CETPALDH1A1TSHRCYP3A4 | |
| SCHEMBL8562419 | 0.81 | TLR2 (0.43) | TLR2CETPTDP1L3MBTL1PLA2G10 | |
| SCHEMBL10833517 | 0.81 | LPAR1 (0.50) | CETPTSHRPLA2G10PLA2G2A | |
| SCHEMBL10833513 | 0.81 | LPAR1 (0.50) | CETPTSHRPLA2G10PLA2G2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5187293-A | Blood platelet activating factor inhibitors | HOFFMANN-LA ROCHE INC. (US) | 1993-02-16 | — | — | US | disclosed |
| US-4731373-A | BLOOD PLATELET ACTIVATING FACTOR | HOFFMAN-LA ROCHE INC. (US) | 1988-03-15 | — | — | US | disclosed |