⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL251251 | 1.00 | — | — | |
| SCHEMBL148513 | 0.79 | — | — | |
| SCHEMBL865783 | 0.79 | — | — | |
| SCHEMBL863453 | 0.79 | — | — | |
| SCHEMBL17101240 | 0.79 | — | — | |
| SCHEMBL8860920 | 0.76 | LMNA (0.36) | — | |
| SCHEMBL1302931 | 0.76 | LMNA (0.69) | — | |
| SCHEMBL17101325 | 0.76 | LMNA (0.69) | — | |
| SCHEMBL8348104 | 0.76 | LMNA (0.69) | — | |
| SCHEMBL1136539 | 0.76 | LMNA (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1512 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210355067-A1 | NOVEL BIAROMATIC PROPYNYL COMPOUNDS, PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING SAME, AND USES THEREOF | GALDERMA RESEARCH & DEVELOPEMENT (FR) | 2021-11-18 | — | — | US | claimed |
| US-10995052-B2 | Biaromatic propynyl compounds, pharmaceutical and cosmetic compositions containing same, and uses thereof | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2021-05-04 | — | — | US | claimed |
| US-20190337881-A1 | NOVEL BIAROMATIC PROPYNYL COMPOUNDS, PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING SAME, AND USES THEREOF | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2019-11-07 | — | — | US | claimed |
| CN-109414384-A | New double aromatic radical propinyl compounds, drug and cosmetic composition comprising the compound and application thereof | 高德美研究及发展公司 | 2019-03-01 | — | — | CN | claimed |
| EP-3411010-A1 | NOVEL BIAROMATIC PROPYNYL COMPOUNDS, PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING SAME, AND USES THEREOF | Galderma Research & Development (FR) | 2018-12-12 | — | — | EP | claimed |
| US-20180079707-A1 | NEW BI-AROMATIC PROPYNYL COMPOUNDS, PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM AND USES THEREOF | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2018-03-22 | — | — | US | claimed |
| US-20170313661-A1 | KINASE MODULATORS FOR THE TREATMENT OF CANCER | SYNOVO GMBH (DE) | 2017-11-02 | — | — | US | claimed |
| WO-2017134513-A1 | NOVEL BIAROMATIC PROPYNYL COMPOUNDS, PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING SAME, AND USES THEREOF | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2017-08-10 | — | — | WO | claimed |
| US-8765805-B2 | Ligand activators of the RAR receptors and pharmaceutical/cosmetic applications thereof | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2014-07-01 | — | — | US | claimed |
| US-20130045938-A1 | KINASE MODULATORS FOR THE TREATMENT OF CANCER | SYNOVO GMBH (DE) | 2013-02-21 | — | — | US | claimed |
| US-5004835-A | Substituted dicarboxylic acid-bis(3,5-dicarbamoyl-2,4,6-triiodoanilides), process for their production as well as X-ray contrast media containing them | SCHERING AKTIENGESELLSCHAFT (DE) | 1991-04-02 | — | — | US | claimed |
| EP-0409728-A2 | Bi-aromatic esters, process for their preparation and their use in human or animal medicine and in cosmetics | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA, ( CIRD GALDERMA) (FR) | 1991-01-23 | — | — | EP | claimed |
| EP-0409729-A1 | Bi-aromatic thioesters, process for their preparation and their use in human or veterinary medicine and in cosmetics | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA, ( CIRD GALDERMA) (FR) | 1991-01-23 | — | — | EP | claimed |
| EP-0292348-B1 | POLYCYCLIC HETEROCYCLIC DERIVATIVES, PROCES FOR THEIR PREPARATION AND THEIR USE IN HUMAN AND VETERINARY MEDICINES | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA - CIRD GALDERMA Groupement d'Intérêt Economique dit: (FR) | 1990-09-19 | — | — | EP | claimed |
| US-4925658-A | TREATMENT OF DERMATOLOGIC, RHEUMATIC, RESPIRATORY, OPHTHALMOLOGIC DISORDERS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (CIRD) (FR) | 1990-05-15 | — | — | US | claimed |
| US-4918176-A | SYSTEMIC AND TOPICAL TREATMENT OF DERMATOLOGIC DISORDERS | SOCIETE ANONYME DITE: L'OREAL (FR) | 1990-04-17 | — | — | US | claimed |
| EP-0325540-A1 | Aromatic esters and thioesters, process for their preparation and their use in human or animal therapeutics and in cosmetics | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA - CIRD GALDERMA (FR) | 1989-07-26 | — | — | EP | claimed |
| EP-0232199-A2 | Aromatic benzamido compounds, process for their preparation and their use in human or veterinary medicine as well as in cosmetics | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA - CIRD GALDERMA (FR) | 1987-08-12 | — | — | EP | claimed |
| EP-0007996-B1 | 4,6-DI-0-(AMINOGLYCOSYL)-1,3-DIAMINOCYCLITOLS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BAYER AG (DE) | 1983-01-26 | — | — | EP | claimed |
| US-4182757-A | Novel nitrosourea compounds and process for preparing the same | TANABE SEIYAKU CO., LTD. (JP) | 1980-01-08 | — | — | US | claimed |