Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.30 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21114727 | 0.94 | TSHR (0.44) | TSHRTHRBLMNASLC22A1 | |
| SCHEMBL38654723 | 0.84 | TSHR (0.40) | TSHRTHRBLMNA | |
| SCHEMBL15847538 | 0.84 | TSHR (0.40) | TSHRTHRBLMNA | |
| SCHEMBL30466502 | 0.84 | TSHR (0.40) | TSHRTHRBLMNA | |
| SCHEMBL31196697 | 0.84 | TSHR (0.40) | TSHRTHRBLMNA | |
| SCHEMBL38655990 | 0.84 | TSHR (0.40) | TSHRTHRBLMNA | |
| SCHEMBL31084192 | 0.84 | TSHR (0.40) | TSHRTHRBLMNA | |
| SCHEMBL2513042 | 0.84 | TSHR (0.40) | TSHRTHRBLMNA | |
| SCHEMBL6031856 | 0.84 | TSHR (0.33) | TSHRTHRBLMNA | |
| SCHEMBL30466503 | 0.84 | TSHR (0.40) | TSHRTHRBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2462111-A1 | PREPARATION OF (R)- AND (S)-N-(3, 4-DIFLUORO-2-(2-FLUORO-4-IODOPHENYLAMINO)--6-METHOXYPHENYL) -1- (2, 3-DIHYDROXYPROPYL)CYCLOPROPANE-1-SULFONAMIDE AND PROTECTED DERIVATIVES THEREOF | Ardea Biosciences, Inc. (US) | 2012-06-13 | — | — | EP | disclosed |
| WO-2011009541-A1 | PREPARATION OF (R)- AND (S)-N-(3, 4-DIFLUORO-2-(2-FLUORO-4-IODOPHENYLAMINO)--6-METHOXYPHENYL) -1- (2, 3-DIHYDROXYPROPYL)CYCLOPROPANE-1-SULFONAMIDE AND PROTECTED DERIVATIVES THEREOF | ARDEA BIOSCIENCES, INC. (US) | 2011-01-27 | — | — | WO | disclosed |