Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GNAI3 | P08754 | 5/20 | 0.38 |
| ▸ | GNAO1 | P09471 | 5/20 | 0.38 |
| ▸ | GNAI1 | P63096 | 5/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.36 |
| ▸ | ADH1B | P00325 | 1/20 | 0.35 |
| ▸ | ADH1A | P07327 | 1/20 | 0.35 |
| ▸ | ADH7 | P40394 | 1/20 | 0.35 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15445 | 0.79 | — | — | |
| SCHEMBL17626634 | 0.79 | TSHR (0.53) | TSHRCYP2C19ALDH1A1MEN1GLA | |
| SCHEMBL22416418 | 0.77 | HSD17B10 (0.48) | TSHRALDH1A1MEN1KMT2AGNAI3 | |
| SCHEMBL10904114 | 0.76 | CYP2C19 (0.62) | TSHRCYP2C19ALDH1A1MEN1GLA | |
| SCHEMBL6910828 | 0.75 | TSHR (0.50) | TSHRCYP2C19ALDH1A1MEN1GLA | |
| Propane SCHEMBL20526066 | 0.75 | TSHR (0.50) | TSHRCYP2C19ALDH1A1MEN1GLA | |
| SCHEMBL7184374 | 0.75 | — | — | |
| SCHEMBL21176007 | 0.75 | — | — | |
| SCHEMBL6934656 | 0.75 | TSHR (0.50) | TSHRCYP2C19ALDH1A1MEN1GLA | |
| Piperazine SCHEMBL2842298 | 0.75 | HIF1A (0.55) | ALDH1A1GNAI3GNAO1GNAI1HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0527237-A1 | BIAXIALLY ORIENTED POLYAMIDE LAMINATE FILM | Mitsubishi Chemical Corporation (JP) | 1993-02-17 | — | — | EP | disclosed |