Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | MGAM | O43451 | 1/20 | 0.42 |
| ▸ | SI | P14410 | 1/20 | 0.42 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.42 |
| ▸ | PPID | Q08752 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9581896 | 1.00 | SMN1; SMN2 (0.47) | SMN1; SMN2MAPTMEN1KMT2AL3MBTL1 | |
| SCHEMBL7300693 | 0.89 | MAPT (0.48) | SMN1; SMN2MAPTMEN1KMT2AL3MBTL1 | |
| SCHEMBL24451168 | 0.86 | SMN1; SMN2 (0.49) | SMN1; SMN2MAPTMEN1KMT2AL3MBTL1 | |
| SCHEMBL6524085 | 0.85 | MAPT (0.50) | SMN1; SMN2MAPTMEN1KMT2AL3MBTL1 | |
| SCHEMBL30040031 | 0.85 | MAPT (0.50) | SMN1; SMN2MAPTMEN1KMT2AL3MBTL1 | |
| SCHEMBL6524082 | 0.85 | MAPT (0.50) | SMN1; SMN2MAPTMEN1KMT2AL3MBTL1 | |
| SCHEMBL9262217 | 0.84 | MAPT (0.49) | SMN1; SMN2MAPTMEN1KMT2APTGS2 | |
| SCHEMBL9262221 | 0.84 | MAPT (0.49) | SMN1; SMN2MAPTMEN1KMT2APTGS2 | |
| SCHEMBL24158282 | 0.84 | AKT1 (0.47) | SMN1; SMN2MAPTMEN1KMT2AL3MBTL1 | |
| SCHEMBL27825976 | 0.83 | TBXAS1 (0.50) | SMN1; SMN2MAPTMEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5256673-A | Indole-3-yl-A-tetrahydropyridyl or piperidyl compounds | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1993-10-26 | — | — | US | disclosed |
| EP-0144012-B1 | INDOLE DERIVATIVES | MERCK PATENT GmbH (DE) | 1988-03-16 | — | — | EP | disclosed |
| US-4698351-A | Tetrahydrocarbazole derivatives and pharmaceutical compositions | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 1987-10-06 | — | — | US | disclosed |
| US-4618614-A | Method of treating psychosis using tetrahydrocarbazole derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1986-10-21 | — | — | US | disclosed |
| US-4617309-A | Sulfur-containing indole derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1986-10-14 | — | — | US | disclosed |
| EP-0105397-B1 | SULPHURIC INDOLE DERIVATIVES | MERCK PATENT GmbH (DE) | 1986-07-16 | — | — | EP | disclosed |
| US-4547576-A | Tetrahydrocarbazole derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1985-10-15 | — | — | US | disclosed |
| EP-0144012-A1 | Indole derivatives | MERCK PATENT GmbH (DE) | 1985-06-12 | — | — | EP | disclosed |
| EP-0115607-A1 | Tetrahydrocarbazol derivatives | MERCK PATENT GmbH (DE) | 1984-08-15 | — | — | EP | disclosed |
| EP-0105397-A1 | Sulphuric indole derivatives | MERCK PATENT GmbH (DE) | 1984-04-18 | — | — | EP | disclosed |