Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | MMP14 | P50281 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.39 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9582701 | 0.99 | ALDH1A1 (0.43) | ALDH1A1TDP1HTTKDM4EMEN1 | |
| SCHEMBL9001661 | 0.84 | ALDH1A1 (0.42) | ALDH1A1AOC3 | |
| SCHEMBL10565227 | 0.83 | GAA (0.38) | ALDH1A1TDP1KDM4EGAAMAPT | |
| Hydrochloric Acid SCHEMBL9582763 | 0.83 | ALDH1A1 (0.41) | ALDH1A1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL9001659 | 0.83 | ALDH1A1 (0.41) | ALDH1A1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL9582349 | 0.82 | TDP1 (0.37) | ALDH1A1TDP1KDM4EGAAMAPT | |
| SCHEMBL9583350 | 0.82 | ALDH1A1 (0.37) | ALDH1A1HTTCYP2D6HDAC1MAPK1 | |
| SCHEMBL9583573 | 0.82 | POLB (0.41) | ALDH1A1TDP1MAPTCYP2D6SMN1; SMN2 | |
| SCHEMBL8945848 | 0.79 | CYP3A4 (0.42) | ALDH1A1GAAMAPTCYP2C19 | |
| Hydrochloric Acid SCHEMBL11263395 | 0.79 | CYP1A2 (0.58) | ALDH1A1TDP1HTTKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4822914-A | 2-amino-N-methyl-α-phenyl-phenethylamines | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1989-04-18 | — | — | US | claimed |
| US-5260339-A | 4-phenyl-1,3-benzodiazepines and 2-amino-α-phenylphenethylamines for treating convulsions and protecting neurons | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-11-09 | — | — | US | disclosed |
| US-5185465-A | Carboxamides of 2-amino-alpha-phenlphenethylamines | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1993-02-09 | — | — | US | disclosed |
| US-4968721-A | 2-amino-alpha-phenylphenethylamines and method of use | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1990-11-06 | — | — | US | disclosed |
| US-4933493-A | Intermediates for the preparation of 4-phenyl-1,3-benzodiazepines | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1990-06-12 | — | — | US | disclosed |
| US-4855502-A | CHEMICAL INTERMEDIATES FOR 1,3-BENZODIAZEPINES | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1989-08-08 | — | — | US | disclosed |
| US-4822914-A | 2-amino-N-methyl-α-phenyl-phenethylamines | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1989-04-18 | — | — | US | disclosed |
| US-RE32444-E | Process for preparing 4-phenyl-1,3-benzodiazepines | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1987-06-23 | — | — | US | disclosed |
| US-4504680-A | 4-Phenyl-1,3-benzodiazepines | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1985-03-12 | — | — | US | disclosed |
| US-4469889-A | 2-(2-Nitrophenyl)-1-phenylethanone oxime acetates | HOECHST-ROUSSEL PHARMACEUTICALS, INCORPORATED (US) | 1984-09-04 | — | — | US | disclosed |
| US-4462933-A | Process for preparing 4-phenyl-1,3-benzodiazepines | HOECHST-ROUSSEL PHARMACEUTICALS, INCORPORATED (US) | 1984-07-31 | — | — | US | disclosed |
| US-4459230-A | Process for preparing 4-phenyl-1,3-benzodiazepines | HOECHST-ROUSSEL PHARMACEUTICALS, INCORPORATED (US) | 1984-07-10 | — | — | US | disclosed |
| US-4459231-A | Process for preparing 4-phenyl-1,3-benzodiazepines | HOECHST-ROUSSEL PHARMACEUTICALS, INCORPORATED (US) | 1984-07-10 | — | — | US | disclosed |
| US-4409145-A | OXIMINATION, ESTERIFICATION, REDUCTION | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1983-10-11 | — | — | US | disclosed |
| EP-0009800-B1 | 4-PHENYL-1,3-BENZODIAZEPINES, METHOD FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THE COMPOUNDS FOR USE AS MEDICAMENTS | HOECHST AKTIENGESELLSCHAFT (DE) | 1983-02-23 | — | — | EP | disclosed |
| US-4309424-A | 4-Phenyl-1,3-benzodiazepines | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1982-01-05 | — | — | US | disclosed |
| EP-0009800-A2 | 4-Phenyl-1,3-benzodiazepines, method for their preparation, pharmaceutical compositions containing them, and the compounds for use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1980-04-16 | — | — | EP | disclosed |