Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 11/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | BPTF | Q12830 | 1/20 | 0.64 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.42 |
| ▸ | NPY1R | P25929 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Octaaminoacridine SCHEMBL12507982 | 0.82 | ACHE (1.00) | ACHEMAPK1MEN1KMT2ABPTF | |
| Ipidacrine SCHEMBL29382648 | 0.80 | ACHE (1.00) | ACHEMAPK1MEN1KMT2ABPTF | |
| Ipidacrine SCHEMBL28251 | 0.80 | ACHE (1.00) | ACHEMAPK1MEN1KMT2ABPTF | |
| Ipidacrine SCHEMBL7536973 | 0.78 | ACHE (0.95) | ACHEMAPK1MEN1KMT2ABPTF | |
| Ipidacrine SCHEMBL1032513 | 0.78 | ACHE (0.95) | ACHEMAPK1MEN1KMT2ABPTF | |
| SCHEMBL20681035 | 0.77 | ACHE (0.95) | ACHEMAPK1MEN1KMT2ABPTF | |
| Ipidacrine SCHEMBL6633743 | 0.76 | ACHE (0.91) | ACHEMAPK1MEN1KMT2ABPTF | |
| Ipidacrine SCHEMBL29751898 | 0.76 | ACHE (0.91) | ACHEMAPK1MEN1KMT2ABPTF | |
| SCHEMBL22021195 | 0.73 | ACHE (0.86) | ACHEMAPK1MEN1KMT2ABPTF | |
| SCHEMBL30162181 | 0.73 | ACHE (0.86) | ACHEMAPK1MEN1KMT2ABPTF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5202440-A | Certain 9-amino-2-(or 4)-oxa 1,2,3,4-tetrahydro- or 1,2,3,4,5,6,7,8-octahydro-acridines | PFIZER INC. (US) | 1993-04-13 | — | — | US | disclosed |
| CN-1032440-A | The 4-aminopyridine derivatives class | PFIZER (US) | 1989-04-19 | — | — | CN | disclosed |
| EP-0311303-A2 | 4-aminopyridine derivatives | PFIZER INC. (US) | 1989-04-12 | — | — | EP | disclosed |
| WO-1989002739-A1 | 4-AMINOPYRIDINE DERIVATIVES | PFIZER INC. (US) | 1989-04-06 | — | — | WO | disclosed |
| WO-1989002740-A1 | 4-AMINOPYRIDINE DERIVATIVES | PFIZER INC. (US) | 1989-04-06 | — | — | WO | disclosed |