Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKD1 | Q15139 | 7/20 | 0.72 |
| ▸ | CTSK | P43235 | 7/20 | 0.46 |
| ▸ | CTSL | P07711 | 4/20 | 0.46 |
| ▸ | JAK2 | O60674 | 5/20 | 0.45 |
| ▸ | JAK3 | P52333 | 3/20 | 0.45 |
| ▸ | CTSB | P07858 | 6/20 | 0.45 |
| ▸ | CTSS | P25774 | 5/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL936515 | 0.84 | PRKD1 (1.00) | PRKD1CTSKCTSLJAK2JAK3 | |
| SCHEMBL6923791 | 0.81 | PRKD1 (0.95) | PRKD1CTSKCTSLJAK2JAK3 | |
| SCHEMBL958404 | 0.77 | PRKD1 (0.85) | PRKD1CTSKCTSLJAK2 | |
| SCHEMBL1056918 | 0.73 | PRKD1 (0.76) | PRKD1CTSKCTSLJAK2JAK3 | |
| SCHEMBL936000 | 0.72 | PRKD1 (0.78) | PRKD1JAK2JAK3 | |
| SCHEMBL6923773 | 0.72 | PRKD1 (0.78) | PRKD1JAK2 | |
| SCHEMBL936598 | 0.72 | PRKD1 (1.00) | PRKD1 | |
| SCHEMBL936600 | 0.72 | PRKD1 (1.00) | PRKD1 | |
| SCHEMBL936281 | 0.71 | PRKD1 (0.73) | PRKD1CTSK | |
| SCHEMBL936790 | 0.71 | PRKD1 (0.76) | PRKD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011009484-A1 | ARYLPYRAZOLES AND ARYLISOXAZOLES AND THEIR USE AS PKD MODULATORS | NOVARTIS AG (CH) | 2011-01-27 | — | — | WO | disclosed |