Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 1/20 | 0.46 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | F10 | P00742 | 1/20 | 0.44 |
| ▸ | TACR1 | P25103 | 7/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | THRA | P10827 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9584177 | 0.93 | MAPT (0.49) | FOLH1PLA2G2AF10POLBMAPT | |
| Hydrochloric Acid SCHEMBL9584113 | 0.92 | MAPT (0.48) | FOLH1PLA2G2AF10POLBMAPT | |
| SCHEMBL9584600 | 0.91 | PTGDR2 (0.50) | FOLH1PLA2G2APOLBPTGDR2HDAC1 | |
| SCHEMBL9585090 | 0.88 | CCR1 (0.47) | FOLH1F10POLBMAPTMAPK10 | |
| SCHEMBL9584407 | 0.87 | FOLH1 (0.52) | FOLH1PLA2G2APOLBPTGDR2MAPT | |
| SCHEMBL9585264 | 0.85 | F10 (0.48) | PLA2G2AF10POLBMAPTMAPK10 | |
| SCHEMBL9584118 | 0.84 | MAPT (0.47) | PLA2G2AF10POLBMAPTMAPK10 | |
| SCHEMBL9603261 | 0.83 | EPHX2 (0.46) | FOLH1PLA2G2APOLBPTGDR2MAPT | |
| SCHEMBL9584250 | 0.83 | AKR1C3 (0.51) | PLA2G2APOLBPTGDR2MAPTMAPK10 | |
| SCHEMBL9585467 | 0.83 | LMNA (0.45) | PLA2G2AMAPTMAPK10HDAC1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5245046-A | α-amino-indole-3-acetic acids useful as anti-diabetic, anti-obesity and anti-atherosclerotic agents | THE UPJOHN COMPANY (US) | 1993-09-14 | — | — | US | disclosed |
| EP-0375133-A1 | Alpha-amino-indole-3-acetic acids useful as anti-diabetic, anti-obesity and anti-atherosclerotic agents | THE UPJOHN COMPANY (US) | 1990-06-27 | — | — | EP | disclosed |
| WO-1990005721-A1 | ALPHA-AMINO-INDOLE-3-ACETIC ACIDS USEFUL AS ANTI-DIABETIC, ANTI-OBESITY AND ANTI-ATHEROSCLEROTIC AGENTS | THE UPJOHN COMPANY (US) | 1990-05-31 | — | — | WO | disclosed |