Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 16/20 | 1.00 |
| ▸ | BCHE | P06276 | 5/20 | 0.61 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.61 |
| ▸ | GRIN2A | Q12879 | 4/20 | 0.61 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17992251 | 0.81 | ACHE (0.68) | ACHEBCHEGRIN1GRIN2A | |
| SCHEMBL21938740 | 0.81 | ACHE (0.68) | ACHEBCHEGRIN1GRIN2ACHRM1 | |
| SCHEMBL9215322 | 0.81 | ACHE (1.00) | ACHEBCHEGRIN1GRIN2ACHRM1 | |
| SCHEMBL8006170 | 0.76 | ACHE (1.00) | ACHEBCHEGRIN1GRIN2ACHRM1 | |
| Hydrochloric Acid SCHEMBL29817833 | 0.75 | ACHE (1.00) | ACHEBCHEGRIN1GRIN2ACHRM1 | |
| Hydrochloric Acid SCHEMBL29817811 | 0.75 | ACHE (1.00) | ACHEBCHEGRIN1GRIN2ACHRM1 | |
| SCHEMBL9584489 | 0.74 | ACHE (0.63) | ACHEBCHEGRIN1GRIN2ACHRM1 | |
| Hydrochloric Acid SCHEMBL29817663 | 0.74 | ACHE (1.00) | ACHEBCHEGRIN1GRIN2ACHRM1 | |
| SCHEMBL10286361 | 0.72 | ACHE (0.69) | ACHEBCHEGRIN1GRIN2ACHRM1 | |
| SCHEMBL29120934 | 0.72 | ACHE (0.56) | ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5202440-A | Certain 9-amino-2-(or 4)-oxa 1,2,3,4-tetrahydro- or 1,2,3,4,5,6,7,8-octahydro-acridines | PFIZER INC. (US) | 1993-04-13 | — | — | US | disclosed |
| EP-0311303-A2 | 4-aminopyridine derivatives | PFIZER INC. (US) | 1989-04-12 | — | — | EP | disclosed |
| WO-1989002740-A1 | 4-AMINOPYRIDINE DERIVATIVES | PFIZER INC. (US) | 1989-04-06 | — | — | WO | disclosed |