Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | BCR | P11274 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA3 | P07451 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9585998 | 0.86 | TSHR (0.57) | TSHRMAPK1CYP1A2LMNAAGTR1 | |
| SCHEMBL7736874 | 0.82 | TSHR (0.60) | TSHRMAPK1CYP1A2LMNAAGTR1 | |
| SCHEMBL8844964 | 0.81 | TSHR (0.64) | TSHRMAPK1CYP1A2LMNAAGTR1 | |
| SCHEMBL26326238 | 0.79 | TSHR (0.63) | TSHRMAPK1CYP1A2LMNAAGTR1 | |
| SCHEMBL9935223 | 0.79 | TSHR (0.51) | TSHRMAPK1CYP1A2LMNAAGTR1 | |
| SCHEMBL9272295 | 0.77 | ALDH1A1 (0.46) | TSHRMAPK1CYP1A2LMNAAGTR1 | |
| Sulfuric Acid SCHEMBL28460852 | 0.76 | TSHR (0.54) | TSHRMAPK1CYP1A2LMNAAGTR1 | |
| SCHEMBL4683475 | 0.75 | TSHR (0.56) | TSHRMAPK1CYP1A2LMNAAGTR1 | |
| SCHEMBL4689656 | 0.75 | TSHR (0.56) | TSHRMAPK1CYP1A2LMNAAGTR1 | |
| SCHEMBL15241111 | 0.75 | CYP3A4 (0.47) | TSHRCYP1A2LMNAAGTR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5212316-A | Respiratory system disorders | BOEHRINGER MANNHEIM ITALIA (IT) | 1993-05-18 | — | — | US | disclosed |
| EP-0303227-B1 | ETHERS AND THIOETHERS HAVING THERAPEUTICAL ACTIVITY, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1992-02-05 | — | — | EP | disclosed |
| US-4968706-A | MUCOLYTIC, ANTITUSSIVE, BRONCHODILATOR, ANTIINFLAMMATORY | BOEHRINGER MANNHEIN ITALIA, S.P.A. (IT) | 1990-11-06 | — | — | US | disclosed |
| EP-0303227-A1 | Ethers and thioethers having therapeutical activity, their preparation and pharmaceutical compositions containing them | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1989-02-15 | — | — | EP | disclosed |