SCHEMBL9587372

SCHEMBL9587372

COc1cc(C(C)(C)C)c(O[Zr](C)(Oc2c(C(C)(C)C)cc(OC)cc2C(C)(C)C)Oc2c(C(C)(C)C)cc(OC)cc2C(C)(C)C)c(C(C)(C)C)c1

nearest known ligand 0.53

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CA1 P00915 1/20 0.53
CA2 P00918 1/20 0.53
ALDH1A1 P00352 3/20 0.39
GAA P10253 1/20 0.35
TNFRSF1A P19438 1/20 0.35
PTGS2 P35354 3/20 0.34
CYP3A4 P08684 2/20 0.33
LMNA P02545 1/20 0.33
TP53 P04637 1/20 0.33
HPGD P15428 1/20 0.33
ALOX15 P16050 1/20 0.33
TSHR P16473 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
CYP1A1 P04798 1/20 0.31
CYP1B1 Q16678 1/20 0.31
PTGS1 P23219 1/20 0.31
EGFR P00533 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9587049 0.86 CA1 (0.55) CA1CA2ALDH1A1GAATNFRSF1A
SCHEMBL22360314 0.81 CA1 (0.64) CA1CA2ALDH1A1GAATNFRSF1A
SCHEMBL9587005 0.79 SMN1; SMN2 (0.46) CA2ALDH1A1CYP3A4ALOX15TSHR
SCHEMBL4437362 0.73 CA1 (0.55) CA1CA2ALDH1A1GAATNFRSF1A
SCHEMBL5090250 0.73 CA2 (0.55) CA1CA2ALDH1A1GAATNFRSF1A
SCHEMBL15180056 0.73 CA1 (0.55) CA1CA2ALDH1A1GAATNFRSF1A
SCHEMBL15180064 0.73 CA1 (0.55) CA1CA2ALDH1A1GAATNFRSF1A
SCHEMBL6672713 0.73 CA1 (0.55) CA1CA2ALDH1A1GAATNFRSF1A
SCHEMBL1512024 0.73 CA1 (0.55) CA1CA2ALDH1A1GAATNFRSF1A
SCHEMBL9587156 0.72 CA2 (0.44) CA2ALDH1A1TSHRTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0539446-A1 GROUP IVB, VB AND VIB METAL HYDROCARBYLOXIDES, WITH ALUMOXANE FOR OLEFIN POLYMERIZATION EXXON CHEMICAL PATENTS INC. (US) 1993-05-05 EP disclosed
WO-1992001006-A1 GROUP IVB, VB AND VIB METAL HYDROCARBYLOXIDES, WITH ALUMOXANE FOR OLEFIN POLYMERIZATION EXXON CHEMICAL PATENTS INC. (US) 1992-01-23 WO disclosed
US-5079205-A GROUP IVB, VB AND VIB METAL HYDROCARBYLOXIDES, WITH ALUMOXANE FOR OLEFIN POLYMERIZATION EXXON CHEMICAL PATENTS INC. (US) 1992-01-07 US disclosed