Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 4/20 | 0.35 |
| ▸ | BRD4 | O60885 | 3/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | PNP | P00491 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | NSD2 | O96028 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | DHFR | P00374 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | GALR3 | O60755 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9590686 | 0.88 | TYMS (0.42) | TYMSDHFRMAOAMAOB | |
| SCHEMBL9378837 | 0.88 | TYMS (0.37) | TYMSMAPK1DHFRGAAMAOA | |
| SCHEMBL9377783 | 0.87 | TYMS (0.42) | TYMSKDM4EDHFRALDH1A1HPGD | |
| SCHEMBL9375105 | 0.84 | PTPN11 (0.34) | TYMSPOLBL3MBTL1DHFR | |
| SCHEMBL9589264 | 0.84 | PNP (0.32) | TYMSPNPKDM4ENSD2MAPT | |
| SCHEMBL9588530 | 0.83 | TYMS (0.41) | TYMSL3MBTL1DHFRALDH1A1 | |
| SCHEMBL9374084 | 0.80 | KDR (0.35) | KDM4EMAPTMAPK1POLBALDH1A1 | |
| SCHEMBL9374095 | 0.80 | KDR (0.35) | KDM4EMAPTMAPK1POLBALDH1A1 | |
| SCHEMBL9587889 | 0.78 | MAPK8 (0.36) | TYMSMAOB | |
| SCHEMBL9590145 | 0.75 | TYMS (0.37) | TYMSPDE3BPDE3ADHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993007137-A1 | PYRIDINOL DERIVATIVES AS MEDICAMENTS | SMITHKLINE BEECHAM PLC (GB) | 1993-04-15 | — | — | WO | claimed |
| WO-1993007137-A1 | PYRIDINOL DERIVATIVES AS MEDICAMENTS | SMITHKLINE BEECHAM PLC (GB) | 1993-04-15 | — | — | WO | disclosed |