Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.73 |
| ▸ | HPGD | P15428 | 4/20 | 0.73 |
| ▸ | GAA | P10253 | 3/20 | 0.73 |
| ▸ | GALR3 | O60755 | 1/20 | 0.73 |
| ▸ | PDE3A | Q14432 | 6/20 | 0.69 |
| ▸ | PDE3B | Q13370 | 5/20 | 0.69 |
| ▸ | PDE4A | P27815 | 3/20 | 0.69 |
| ▸ | BLM | P54132 | 2/20 | 0.69 |
| ▸ | LMNA | P02545 | 2/20 | 0.69 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.69 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.69 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.69 |
| ▸ | PDE5A | O76074 | 1/20 | 0.69 |
| ▸ | TSHR | P16473 | 1/20 | 0.69 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.69 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.69 |
| ▸ | PDE2A | O00408 | 1/20 | 0.58 |
| ▸ | PDE1A | P54750 | 1/20 | 0.58 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8210361 | 0.86 | KDM4E (0.75) | KDM4EALDH1A1HPGDGAAGALR3 | |
| SCHEMBL10891425 | 0.85 | KDM4E (0.73) | KDM4EALDH1A1HPGDGAAGALR3 | |
| SCHEMBL7407595 | 0.85 | KDM4E (0.73) | KDM4EALDH1A1HPGDGAAGALR3 | |
| SCHEMBL5470727 | 0.85 | HPGD (0.73) | KDM4EALDH1A1HPGDGAAGALR3 | |
| SCHEMBL5460125 | 0.84 | KDM4E (1.00) | KDM4EALDH1A1HPGDGAAGALR3 | |
| SCHEMBL19835567 | 0.83 | MCL1 (0.55) | KDM4EALDH1A1HPGDGAAGALR3 | |
| SCHEMBL19835568 | 0.83 | KDM4E (0.51) | KDM4EALDH1A1HPGDGAAGALR3 | |
| SCHEMBL11003142 | 0.82 | KDM4E (0.69) | KDM4EALDH1A1HPGDGAAGALR3 | |
| SCHEMBL11006102 | 0.82 | KDM4E (0.69) | KDM4EALDH1A1HPGDGAAGALR3 | |
| SCHEMBL5480537 | 0.82 | KDM4E (0.69) | KDM4EALDH1A1HPGDGAAGALR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993007137-A1 | PYRIDINOL DERIVATIVES AS MEDICAMENTS | SMITHKLINE BEECHAM PLC (GB) | 1993-04-15 | — | — | WO | disclosed |