SCHEMBL9587768

SCHEMBL9587768

NCCNC(=O)c1ncsc1-c1ccccc1F

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.65
CYP3A4 P08684 1/20 0.65
THPO P40225 1/20 0.65
LMNA P02545 1/20 0.64
PMP22 Q01453 1/20 0.64
HIF1A Q16665 1/20 0.41
HSD17B13 Q7Z5P4 1/20 0.40
ALDH1A1 P00352 2/20 0.39
MAPT P10636 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
KDM4E B2RXH2 3/20 0.38
MAOB P27338 1/20 0.38
ADORA2A P29274 3/20 0.38
ADORA1 P30542 3/20 0.38
HPGD P15428 1/20 0.37
TSHR P16473 1/20 0.37
HSD17B10 Q99714 1/20 0.37
CHEK1 O14757 1/20 0.36
ATR Q13535 1/20 0.36
GABRA1 P14867 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL9586082 0.99 PMP22 (0.66) CYP1A2CYP3A4THPOLMNAPMP22
SCHEMBL9586654 0.89 CYP1A2 (0.52) CYP1A2CYP3A4THPOLMNAPMP22
Hydrochloric Acid SCHEMBL9586465 0.85 PMP22 (0.58) CYP1A2CYP3A4THPOLMNAPMP22
SCHEMBL9585750 0.85 CYP1A2 (0.69) CYP1A2CYP3A4THPOLMNAPMP22
Hydrochloric Acid SCHEMBL9586968 0.85 PMP22 (0.58) CYP1A2CYP3A4THPOLMNAPMP22
Hydrochloric Acid SCHEMBL9586702 0.84 LMNA (0.70) CYP1A2CYP3A4THPOLMNAPMP22
SCHEMBL9586621 0.83 CYP1A2 (0.73) CYP1A2CYP3A4THPOLMNAPMP22
Hydrochloric Acid SCHEMBL9587334 0.82 LMNA (0.55) CYP1A2CYP3A4THPOLMNAPMP22
Hydrochloric Acid SCHEMBL9587453 0.82 PMP22 (0.74) CYP1A2CYP3A4THPOLMNAPMP22
Hydrochloric Acid SCHEMBL9586483 0.81 PMP22 (0.59) CYP1A2CYP3A4THPOLMNAPMP22

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5204482-A Ethylenediamine monoamide heteroaryl derivatives HOFFMAN-LAROCHE INC. (US) 1993-04-20 US disclosed
US-5011849-A Monoamine oxidase inhibitors HOFFMANN-LA ROCHE INC. (US) 1991-04-30 US disclosed
EP-0352581-A2 Ethylene diaminmonoamide derivatives F. HOFFMANN-LA ROCHE AG (CH) 1990-01-31 EP disclosed