Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 17/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 17/20 | 0.43 |
| ▸ | PDE4A | P27815 | 4/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9589005 | 0.76 | PDE3B (0.67) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL9588042 | 0.73 | PDE3B (0.69) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL11393595 | 0.72 | PDE4A (0.39) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL20138813 | 0.70 | PDE4A (0.40) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL20159190 | 0.70 | PDE4A (0.40) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL20142927 | 0.70 | PDE4A (0.40) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL11322162 | 0.70 | PDE4A (0.51) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10333467 | 0.67 | MAPT (0.46) | PDE3BPDE3A | |
| SCHEMBL10333455 | 0.67 | MAPT (0.49) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL2474488 | 0.66 | METAP1 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5221742-A | PROCESS FOR THE PREPARATION OF 6-(3,4-DIHYDRO-3-OXO-1,4(2H)-BENZOXAZIN-7-YL)-2,3,4,5-TETRAHYDROPYRIDAZIN-3-ONES | ORTHO PHARMACEUTICAL CORPORATION (US) | 1993-06-22 | — | — | US | disclosed |
| WO-1992011256-A1 | PROCESS FOR THE PREPARATION OF BENZOXAZINYLTETRAHYDROPYRIDAZINES | ORTHO PHARMACEUTICAL CORPORATION (US) | 1992-07-09 | — | — | WO | disclosed |