Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 3/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 6/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 6/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 3/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20159190 | 1.00 | PDE4A (0.40) | PDE4APDE4BPDE4CPDE4DCYP19A1 | |
| SCHEMBL20138813 | 1.00 | PDE4A (0.40) | PDE4APDE4BPDE4CPDE4DCYP19A1 | |
| SCHEMBL11393595 | 0.83 | PDE4A (0.39) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL20159103 | 0.82 | BRD4 (0.41) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL20159391 | 0.82 | PDE4A (0.38) | PDE4APDE4BPDE4CPDE4DCYP19A1 | |
| SCHEMBL20159390 | 0.81 | PDE4D (0.38) | PDE4APDE4BPDE4CPDE4DCYP19A1 | |
| SCHEMBL20159106 | 0.81 | HRH3 (0.38) | CYP19A1KDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL20159709 | 0.81 | CYP19A1 (0.40) | CYP19A1PDE3BPDE3AKDM4EMEN1 | |
| SCHEMBL20142921 | 0.81 | PDE4B (0.40) | PDE4APDE4BPDE4CPDE4DCYP19A1 | |
| SCHEMBL22130329 | 0.80 | PDE4B (0.36) | PDE4APDE4BPDE4CPDE4DPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018086703-A1 | DIHYDROPYRIDAZINONES SUBSTITUTED WITH PHENYLUREAS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018086703-A1 | DIHYDROPYRIDAZINONES SUBSTITUTED WITH PHENYLUREAS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-17 | — | — | WO | disclosed |