Known targets — ChEMBL curated mechanism
CYP11A1CYP11B1CYP11B2CYP17A1ERG11
The experimentally established mechanism targets of Levoketoconazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP17A1 known ✓ | P05093 | 15/20 | 0.88 |
| ▸ | CYP11B1 known ✓ | P15538 | 14/20 | 0.88 |
| ▸ | CYP11B2 known ✓ | P19099 | 1/20 | 0.88 |
| ▸ | CYP3A4 | P08684 | 19/20 | 0.88 |
| ▸ | CYP21A2 | P08686 | 16/20 | 0.88 |
| ▸ | CYP19A1 | P11511 | 16/20 | 0.88 |
| ▸ | USP2 | O75604 | 2/20 | 0.88 |
| ▸ | MAPT | P10636 | 2/20 | 0.88 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.88 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.88 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.88 |
| ▸ | MEN1 | O00255 | 1/20 | 0.88 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.88 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.88 |
| ▸ | CYP27B1 | O15528 | 1/20 | 0.88 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.88 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.88 |
| ▸ | GMNN | O75496 | 1/20 | 0.88 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.88 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.88 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Levoketoconazole SCHEMBL29384825 | 0.94 | CYP3A4 (1.00) | CYP3A4CYP21A2CYP19A1CYP17A1CYP11B1 | |
| Levoketoconazole SCHEMBL41473 | 0.94 | CYP3A4 (1.00) | CYP3A4CYP21A2CYP19A1CYP17A1CYP11B1 | |
| Levoketoconazole SCHEMBL1517472 | 0.94 | CYP3A4 (1.00) | CYP3A4CYP21A2CYP19A1CYP17A1CYP11B1 | |
| Levoketoconazole SCHEMBL8407 | 0.94 | CYP3A4 (1.00) | CYP3A4CYP21A2CYP19A1CYP17A1CYP11B1 | |
| Ketoconazole SCHEMBL18258319 | 0.94 | CYP3A4 (1.00) | CYP3A4CYP21A2CYP19A1CYP17A1CYP11B1 | |
| Levoketoconazole SCHEMBL24312989 | 0.94 | CYP3A4 (1.00) | CYP3A4CYP21A2CYP19A1CYP17A1CYP11B1 | |
| Ketoconazole SCHEMBL8408 | 0.94 | CYP3A4 (1.00) | CYP3A4CYP21A2CYP19A1CYP17A1CYP11B1 | |
| Levoketoconazole SCHEMBL13575830 | 0.94 | CYP3A4 (1.00) | CYP3A4CYP21A2CYP19A1CYP17A1CYP11B1 | |
| Levoketoconazole SCHEMBL13606596 | 0.94 | CYP3A4 (1.00) | CYP3A4CYP21A2CYP19A1CYP17A1CYP11B1 | |
| Levoketoconazole SCHEMBL29588034 | 0.94 | CYP3A4 (1.00) | CYP3A4CYP21A2CYP19A1CYP17A1CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120329675-A1 | Testing of Biofilm for Anti-microbial Agent Susceptibility | OLSON MERLE E (CA) | 2012-12-27 | — | — | US | disclosed |
| WO-2011009213-A1 | TESTING OF BIOFILM FOR ANTI-MICROBIAL AGENT SUSCEPTIBILITY | INNOVOTECH, INC. (CA) | 2011-01-27 | — | — | WO | disclosed |
| US-20080318269-A1 | Devices and Methods for the Analysis of Biofilm | OLSON MERLE E | 2008-12-25 | — | — | US | disclosed |
| US-20080318268-A1 | Devices and Methods for the Selection of Agents with Efficacy Against Biofilm | OLSON MERLE E | 2008-12-25 | — | — | US | disclosed |
| EP-1915458-A1 | PLATE FOR SELECTION OF ANTIBIOTICS AGAINST BIOFILM INFECTIONS | MBEC BIOPRODUCTS INC. (CA) | 2008-04-30 | — | — | EP | disclosed |
| WO-2008014581-A1 | PLATE FOR SELECTION OF ANTIBIOTICS AGAINST BIOFILM INFECTIONS | MBEC BIOPRODUCTS INC. (CA) | 2008-02-07 | — | — | WO | disclosed |
| WO-2008014580-A1 | PLATE FOR SELECTION OF ANTIBIOTICS AGAINST BIOFILM INFECTIONS | MBEC BIOPRODUCTS INC. (CA) | 2008-02-07 | — | — | WO | disclosed |
| WO-2002005850-A2 | ENHANCEMENT OF THE ACTION OF ANTI-INFECTIVE AGENTS | PITMY INTERNATIONAL N.V. (AN) | 2002-01-24 | — | — | WO | disclosed |